EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment

BACKGROUND: Glioblastoma multiforme (GBM) induces tumor immunosuppression through interacting with tumor-infiltrating microglia or macrophages (TAMs) with an unclear pathogenesis. Enhancer of zeste homolog 2 (EZH2) is abundant in GBM samples and cell lines and is involved in GBM proliferation, cell...

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Detalles Bibliográficos
Autores principales: Yin, Yatao, Qiu, Shuwei, Li, Xiangpen, Huang, Bo, Xu, Yun, Peng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684749/
https://www.ncbi.nlm.nih.gov/pubmed/29132376
http://dx.doi.org/10.1186/s12974-017-0993-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684749/
https://www.ncbi.nlm.nih.gov/pubmed/29132376
http://dx.doi.org/10.1186/s12974-017-0993-4

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