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Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ‐subunit‐containing GABA(A) receptors in dentate gyrus granule cells

THIP (4,5,6,7‐tetrahydroisoxazolo[5,4‐c]pyridin‐3‐ol) is a GABA(A) receptor agonist with varying potencies and efficacies at γ‐subunit‐containing receptors. More importantly, THIP acts as a selective superagonist at δ‐subunit‐containing receptors (δ‐GABA(A)Rs) at clinically relevant concentrations....

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Detalles Bibliográficos
Autores principales:	Simonsen, Charlotte, Boddum, Kim, von Schoubye, Nadia L., Kloppenburg, Alissa, Sønderskov, Kasper, Hansen, Suzanne L., Kristiansen, Uffe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684853/ https://www.ncbi.nlm.nih.gov/pubmed/28805971 http://dx.doi.org/10.1002/prp2.322

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