Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including...

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Detalles Bibliográficos
Autores principales: Zhang, S., Zhang, Y., Qu, J., Che, X., Fan, Y., Hou, K., Guo, T., Deng, G., Song, N., Li, C., Wan, X., Qu, X., Liu, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685060/
https://www.ncbi.nlm.nih.gov/pubmed/29160412
http://dx.doi.org/10.1590/1414-431X20176472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685060/
https://www.ncbi.nlm.nih.gov/pubmed/29160412
http://dx.doi.org/10.1590/1414-431X20176472

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