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Application of Metabolomics to Quality Control of Natural Product Derived Medicines

Metabolomics has been used as a powerful tool for the analysis and quality assessment of the natural product (NP)-derived medicines. It is increasingly being used in the quality control and standardization of NP-derived medicines because they are composed of hundreds of natural compounds. The most c...

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Autores principales: Lee, Kyung-Min, Jeon, Jun-Yeong, Lee, Byeong-Ju, Lee, Hwanhui, Choi, Hyung-Kyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685424/
https://www.ncbi.nlm.nih.gov/pubmed/28605829
http://dx.doi.org/10.4062/biomolther.2016.249
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author Lee, Kyung-Min
Jeon, Jun-Yeong
Lee, Byeong-Ju
Lee, Hwanhui
Choi, Hyung-Kyoon
author_facet Lee, Kyung-Min
Jeon, Jun-Yeong
Lee, Byeong-Ju
Lee, Hwanhui
Choi, Hyung-Kyoon
author_sort Lee, Kyung-Min
collection PubMed
description Metabolomics has been used as a powerful tool for the analysis and quality assessment of the natural product (NP)-derived medicines. It is increasingly being used in the quality control and standardization of NP-derived medicines because they are composed of hundreds of natural compounds. The most common techniques that are used in metabolomics consist of NMR, GC-MS, and LC-MS in combination with multivariate statistical analyses including principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA). Currently, the quality control of the NP-derived medicines is usually conducted using HPLC and is specified by one or two indicators. To create a superior quality control framework and avoid adulterated drugs, it is necessary to be able to determine and establish standards based on multiple ingredients using metabolic profiling and fingerprinting. Therefore, the application of various analytical tools in the quality control of NP-derived medicines forms the major part of this review. Veregen(®) (Medigene AG, Planegg/Martinsried, Germany), which is the first botanical prescription drug approved by US Food and Drug Administration, is reviewed as an example that will hopefully provide future directions and perspectives on metabolomics technologies available for the quality control of NP-derived medicines.
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spelling pubmed-56854242017-11-19 Application of Metabolomics to Quality Control of Natural Product Derived Medicines Lee, Kyung-Min Jeon, Jun-Yeong Lee, Byeong-Ju Lee, Hwanhui Choi, Hyung-Kyoon Biomol Ther (Seoul) Review Metabolomics has been used as a powerful tool for the analysis and quality assessment of the natural product (NP)-derived medicines. It is increasingly being used in the quality control and standardization of NP-derived medicines because they are composed of hundreds of natural compounds. The most common techniques that are used in metabolomics consist of NMR, GC-MS, and LC-MS in combination with multivariate statistical analyses including principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA). Currently, the quality control of the NP-derived medicines is usually conducted using HPLC and is specified by one or two indicators. To create a superior quality control framework and avoid adulterated drugs, it is necessary to be able to determine and establish standards based on multiple ingredients using metabolic profiling and fingerprinting. Therefore, the application of various analytical tools in the quality control of NP-derived medicines forms the major part of this review. Veregen(®) (Medigene AG, Planegg/Martinsried, Germany), which is the first botanical prescription drug approved by US Food and Drug Administration, is reviewed as an example that will hopefully provide future directions and perspectives on metabolomics technologies available for the quality control of NP-derived medicines. The Korean Society of Applied Pharmacology 2017-11 2017-06-14 /pmc/articles/PMC5685424/ /pubmed/28605829 http://dx.doi.org/10.4062/biomolther.2016.249 Text en Copyright © 2017 The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lee, Kyung-Min
Jeon, Jun-Yeong
Lee, Byeong-Ju
Lee, Hwanhui
Choi, Hyung-Kyoon
Application of Metabolomics to Quality Control of Natural Product Derived Medicines
title Application of Metabolomics to Quality Control of Natural Product Derived Medicines
title_full Application of Metabolomics to Quality Control of Natural Product Derived Medicines
title_fullStr Application of Metabolomics to Quality Control of Natural Product Derived Medicines
title_full_unstemmed Application of Metabolomics to Quality Control of Natural Product Derived Medicines
title_short Application of Metabolomics to Quality Control of Natural Product Derived Medicines
title_sort application of metabolomics to quality control of natural product derived medicines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685424/
https://www.ncbi.nlm.nih.gov/pubmed/28605829
http://dx.doi.org/10.4062/biomolther.2016.249
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