Cargando…

α, γ-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines

Pancreatic cancer is one of the most lethal and aggressive cancers in the world. However, no effective treatment is currently available for pancreatic cancer. The objective of this study was to determine the anti-pancreatic cancer effect of α-mangostin (αM) and γ-mangostin (γM) extracted from the pe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Myoungjae, Chin, Young-Won, Lee, Eun Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685430/ https://www.ncbi.nlm.nih.gov/pubmed/28822990 http://dx.doi.org/10.4062/biomolther.2017.074

Ejemplares similares

α-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation
por: Kim, Sung-Jin, et al.
Publicado: (2012)

Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ-Mangostin: In Vitro and In Vivo Evidence
por: Lee, Youngmun, et al.
Publicado: (2019)

α-Mangostin/γ-Cyclodextrin Inclusion Complex: Formation and Thermodynamic Study
por: Suharyani, Ine, et al.
Publicado: (2021)

Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor
por: Yokoyama, Takeshi, et al.
Publicado: (2015)

Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment
por: Tangsuksan, Piyawat, et al.
Publicado: (2021)

Inhibitory Effect of Oat Bran Ethanol Extract on Survival and Gemcitabine Resistance of Pancreatic Cancer Cells
por: Kim, Myoungjae, et al.
Publicado: (2019)

Transcriptome Analysis Illuminates a Hub Role of SREBP2 in Cholesterol Metabolism by α-Mangostin
por: Chae, Hee-Sung, et al.
Publicado: (2020)

α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF
por: Guo, Ming, et al.
Publicado: (2016)

Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer
por: Damaraju, Vijaya L, et al.
Publicado: (2007)

Protective Effect of γ-mangostin Isolated from the Peel of Garcinia mangostana against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells
por: Baek, Ji Yun, et al.
Publicado: (2021)

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity
por: Hu, Zhaoyang, et al.
Publicado: (2016)

α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines
por: Herdiana, Yedi, et al.
Publicado: (2021)

Nanoparticle Drug Delivery Systems for α-Mangostin
por: Wathoni, Nasrul, et al.
Publicado: (2020)

Inhibitory effects of α-Mangostin on T cell cytokine secretion via ORAI1 calcium channel and K(+) channels inhibition
por: Kim, Hyun Jong, et al.
Publicado: (2021)

Molecular docking studies of α-mangostin, γ-mangostin, and xanthone on peroxisome proliferator-activated receptor gamma diphenyl peptidase-4 enzyme, and aldose reductase enzyme as an antidiabetic drug candidate
por: Mahmudah, Rifa’atul, et al.
Publicado: (2021)

Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin
por: Xia, Yun, et al.
Publicado: (2016)

Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by α-Mangostin in MG-63 Cell Lines
por: Park, Sung-Jin, et al.
Publicado: (2018)

Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines
por: Valdez, B C, et al.
Publicado: (2014)

α-Mangostin and lawsone methyl ether in tooth gel synergistically increase its antimicrobial and antibiofilm formation effects in vitro
por: Nittayananta, Wipawee, et al.
Publicado: (2023)

Enhancing Tamoxifen Therapy with α-Mangostin: Synergistic Antiproliferative Effects on Breast Cancer Cells and Potential Reduced Endometrial Impact
por: Vargas-Castro, Rafael, et al.
Publicado: (2023)

Nanoformulations of α-Mangostin for Cancer Drug Delivery System
por: Meylina, Lisna, et al.
Publicado: (2021)

Gemcitabine Therapy in Patients with Advanced Pancreatic Cancer
por: Min, Young Joo, et al.
Publicado: (2002)

Gemcitabine and XCT790, an ERRα inverse agonist, display a synergistic anticancer effect in pancreatic cancer
por: Liu, Shi-lei, et al.
Publicado: (2022)

α‐Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades
por: Shi, Yu, et al.
Publicado: (2019)

Antimicrobial activity of α-mangostin against Staphylococcus species from companion animals in vitro and therapeutic potential of α-mangostin in skin diseases caused by S. pseudintermedius
por: Park, Seong Yong, et al.
Publicado: (2023)

Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone
por: Krishnamachary, Balaji, et al.
Publicado: (2019)

Synergistic Antitumoral Effect of Epigenetic Inhibitors and Gemcitabine in Pancreatic Cancer Cells
por: Maietta, Immacolata, et al.
Publicado: (2022)

Anti-Acanthamoeba synergistic effect of chlorhexidine and Garcinia mangostana extract or α-mangostin against Acanthamoeba triangularis trophozoite and cyst forms
por: Sangkanu, Suthinee, et al.
Publicado: (2021)

Synthesis of nano-α mangostin based on chitosan and Eudragit S 100
por: Herdiana, Yedi, et al.
Publicado: (2020)

The purity identification and radiolabeling of α-mangostin with technetium-99m
por: Muchtaridi, Muchtaridi, et al.
Publicado: (2020)

Water-dispersible unadulterated α-mangostin particles for biomedical applications
por: Bumrung, Jutamad, et al.
Publicado: (2020)

Antimicrobial and Anti-inflammatory Effects of α-Mangostin Soluble Film
por: Tangsuksan, Piyawat, et al.
Publicado: (2022)

The Effect of α-Mangostin and Cisplatin on Ovarian Cancer Cells and the Microenvironment
por: Borzdziłowska, Paulina, et al.
Publicado: (2022)

The metabolic and molecular mechanisms of α-mangostin in cardiometabolic disorders (Review)
por: John, Oliver Dean, et al.
Publicado: (2022)

Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo
por: Chen, Ya-Hui, et al.
Publicado: (2020)

Suppressive effect of α-mangostin for cancer stem cells in colorectal cancer via the Notch pathway
por: Jo, Min Kyoung, et al.
Publicado: (2022)

Inhibition of pancreatic cancer stem cell characteristics by α‐Mangostin: Molecular mechanisms involving Sonic hedgehog and Nanog
por: Ma, Yiming, et al.
Publicado: (2019)

Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage
por: Lee, Dahae, et al.
Publicado: (2018)

Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
por: Daylami, Rouzbeh, et al.
Publicado: (2014)

Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation
por: Li, Junjie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8mng8ec586k5duhpkj325tr7av