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Saturation effects and the concurrency hypothesis: Insights from an analytic model
Sexual partnerships that overlap in time (concurrent relationships) may play a significant role in the HIV epidemic, but the precise effect is unclear. We derive edge-based compartmental models of disease spread in idealized dynamic populations with and without concurrency to allow for an investigat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685581/ https://www.ncbi.nlm.nih.gov/pubmed/29136021 http://dx.doi.org/10.1371/journal.pone.0187938 |
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author | Miller, Joel C. Slim, Anja C. |
author_facet | Miller, Joel C. Slim, Anja C. |
author_sort | Miller, Joel C. |
collection | PubMed |
description | Sexual partnerships that overlap in time (concurrent relationships) may play a significant role in the HIV epidemic, but the precise effect is unclear. We derive edge-based compartmental models of disease spread in idealized dynamic populations with and without concurrency to allow for an investigation of its effects. Our models assume that partnerships change in time and individuals enter and leave the at-risk population. Infected individuals transmit at a constant per-partnership rate to their susceptible partners. In our idealized populations we find regions of parameter space where the existence of concurrent partnerships leads to substantially faster growth and higher equilibrium levels, but also regions in which the existence of concurrent partnerships has very little impact on the growth or the equilibrium. Additionally we find mixed regimes in which concurrency significantly increases the early growth, but has little effect on the ultimate equilibrium level. Guided by model predictions, we discuss general conditions under which concurrent relationships would be expected to have large or small effects in real-world settings. Our observation that the impact of concurrency saturates suggests that concurrency-reducing interventions may be most effective in populations with low to moderate concurrency. |
format | Online Article Text |
id | pubmed-5685581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56855812017-11-30 Saturation effects and the concurrency hypothesis: Insights from an analytic model Miller, Joel C. Slim, Anja C. PLoS One Research Article Sexual partnerships that overlap in time (concurrent relationships) may play a significant role in the HIV epidemic, but the precise effect is unclear. We derive edge-based compartmental models of disease spread in idealized dynamic populations with and without concurrency to allow for an investigation of its effects. Our models assume that partnerships change in time and individuals enter and leave the at-risk population. Infected individuals transmit at a constant per-partnership rate to their susceptible partners. In our idealized populations we find regions of parameter space where the existence of concurrent partnerships leads to substantially faster growth and higher equilibrium levels, but also regions in which the existence of concurrent partnerships has very little impact on the growth or the equilibrium. Additionally we find mixed regimes in which concurrency significantly increases the early growth, but has little effect on the ultimate equilibrium level. Guided by model predictions, we discuss general conditions under which concurrent relationships would be expected to have large or small effects in real-world settings. Our observation that the impact of concurrency saturates suggests that concurrency-reducing interventions may be most effective in populations with low to moderate concurrency. Public Library of Science 2017-11-14 /pmc/articles/PMC5685581/ /pubmed/29136021 http://dx.doi.org/10.1371/journal.pone.0187938 Text en © 2017 Miller, Slim http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Miller, Joel C. Slim, Anja C. Saturation effects and the concurrency hypothesis: Insights from an analytic model |
title | Saturation effects and the concurrency hypothesis: Insights from an analytic model |
title_full | Saturation effects and the concurrency hypothesis: Insights from an analytic model |
title_fullStr | Saturation effects and the concurrency hypothesis: Insights from an analytic model |
title_full_unstemmed | Saturation effects and the concurrency hypothesis: Insights from an analytic model |
title_short | Saturation effects and the concurrency hypothesis: Insights from an analytic model |
title_sort | saturation effects and the concurrency hypothesis: insights from an analytic model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685581/ https://www.ncbi.nlm.nih.gov/pubmed/29136021 http://dx.doi.org/10.1371/journal.pone.0187938 |
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