Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4(+) T cells and human leukaemic T cell lymphoblasts

CD4(+) T cells are key elements in immune responses and inflammation. Activation of T cell receptors in CD4(+) T cells triggers cytosolic Ca(2+) release with subsequent store operated Ca(2+) entry (SOCE), which is accomplished by the pore forming Ca(2+) release activated Ca(2+) (CRAC) channel Orai1...

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Detalles Bibliográficos
Autores principales: Zhang, Shaqiu, al-Maghout, Tamer, Bissinger, Rosi, Zeng, Ni, Pelzl, Lisann, Salker, Madhuri S., Cheng, Anchun, Singh, Yogesh, Lang, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685687/
https://www.ncbi.nlm.nih.gov/pubmed/29163766
http://dx.doi.org/10.18632/oncotarget.20032

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