DHX15 is associated with poor prognosis in acute myeloid leukemia (AML) and regulates cell apoptosis via the NF-kB signaling pathway

The role of DHX15, a newly identified DEAH-box RNA helicase, in leukemogenesis remains elusive. Here, we identified a recurrent mutation in DHX15 (NM_001358:c.664C>G: p.(R222G)) in one familial AML patient and 4/240 sporadic AML patients. Additionally, DHX15 was commonly overexpressed in AML pati...

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Detalles Bibliográficos
Autores principales: Pan, Lili, Li, Yang, Zhang, Hai-Ying, Zheng, Yi, Liu, Xiao-Li, Hu, Zheng, Wang, Yi, Wang, Jing, Cai, Yuan-Hua, Liu, Qiao, Chen, Wan-Ling, Guo, Ying, Huang, Yuan-Mao, Qian, Feng, Jin, Li, Wang, Jiucun, Wang, Shao-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685698/
https://www.ncbi.nlm.nih.gov/pubmed/29163777
http://dx.doi.org/10.18632/oncotarget.20288

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