TM5441, a plasminogen activator inhibitor-1 inhibitor, protects against high fat diet-induced non-alcoholic fatty liver disease

Recent evidences showed that elevation of plasminogen activator inhibitor 1 (PAI-1) was responsible in mediating obesity-induced non-alcoholic fatty liver disease (NAFLD) and metabolic disorders. Here, we investigated the effect of TM5441, an oral PAI-1 inhibitor that lacks of bleeding risk, on high...

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Detalles Bibliográficos
Autores principales: Lee, Seon Myeong, Dorotea, Debra, Jung, Inji, Nakabayashi, Tetsuo, Miyata, Toshio, Ha, Hunjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685706/
https://www.ncbi.nlm.nih.gov/pubmed/29163785
http://dx.doi.org/10.18632/oncotarget.21120

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