Abnormal CYP11A1 gene expression induces excessive autophagy, contributing to the pathogenesis of preeclampsia

OBJECTIVE: In this study, we investigated the exact mechanism by which excessive CYP11A1 expression impairs the placentation process and whether this causes preeclampsia (PE) in an in vivo model. SETTING AND DESIGN: In order to study CYP11A1 overexpression, BeWo cells were transfected with CYP11A1....

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Detalles Bibliográficos
Autores principales: Pan, Tianying, He, Guolin, Chen, Meng, Bao, Chenyi, Chen, Yan, Liu, Guangyu, Zhou, Mi, Li, Shuying, Xu, Wenming, Liu, Xinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685712/
https://www.ncbi.nlm.nih.gov/pubmed/29163791
http://dx.doi.org/10.18632/oncotarget.21158

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