Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis

Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages become extremely prone to an IL-6-dependent expression of arginase-1 (Arg1) and nitric oxide synthase (NOS)2, the prototype markers for alte...

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Detalles Bibliográficos
Autores principales: Schmok, Erik, Abad Dar, Mahin, Behrends, Jochen, Erdmann, Hanna, Rückerl, Dominik, Endermann, Tanja, Heitmann, Lisa, Hessmann, Manuela, Yoshimura, Akihiko, Rose-John, Stefan, Scheller, Jürgen, Schaible, Ulrich Emil, Ehlers, Stefan, Lang, Roland, Hölscher, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686055/
https://www.ncbi.nlm.nih.gov/pubmed/29176982
http://dx.doi.org/10.3389/fimmu.2017.01537

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