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Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormone and adrenal cortex is its main source. Direct e...

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Autores principales: Cavalcante-Silva, Luiz H. A., Lima, Éssia de Almeida, Carvalho, Deyse C. M., de Sales-Neto, José M., Alves, Anne K. de Abreu, Galvão, José G. F. M., da Silva, Juliane S. de França, Rodrigues-Mascarenhas, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686084/
https://www.ncbi.nlm.nih.gov/pubmed/29176951
http://dx.doi.org/10.3389/fphys.2017.00895
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author Cavalcante-Silva, Luiz H. A.
Lima, Éssia de Almeida
Carvalho, Deyse C. M.
de Sales-Neto, José M.
Alves, Anne K. de Abreu
Galvão, José G. F. M.
da Silva, Juliane S. de França
Rodrigues-Mascarenhas, Sandra
author_facet Cavalcante-Silva, Luiz H. A.
Lima, Éssia de Almeida
Carvalho, Deyse C. M.
de Sales-Neto, José M.
Alves, Anne K. de Abreu
Galvão, José G. F. M.
da Silva, Juliane S. de França
Rodrigues-Mascarenhas, Sandra
author_sort Cavalcante-Silva, Luiz H. A.
collection PubMed
description Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormone and adrenal cortex is its main source. Direct effects of ouabain are originated due to the binding to its receptor, the Na(+)/K(+)-ATPase, on target cells. This interaction can promote Na(+) transport blockade or even activation of signaling transduction pathways (e.g., EGFR/Src-Ras-ERK pathway activation), independent of ion transport. Besides the well-known effect of ouabain on the cardiovascular system and blood pressure control, compelling evidence indicates that ouabain regulates a number of immune functions. Inflammation is a tightly coordinated immunological function that is also affected by ouabain. Indeed, this hormone can modulate many inflammatory events such as cell migration, vascular permeability, and cytokine production. Moreover, ouabain also interferes on neuroinflammation. However, it is not clear how ouabain controls these events. In this brief review, we summarize the updates of ouabain effect on several aspects of peripheral and central inflammation, bringing new insights into ouabain functions on the immune system.
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spelling pubmed-56860842017-11-24 Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain Cavalcante-Silva, Luiz H. A. Lima, Éssia de Almeida Carvalho, Deyse C. M. de Sales-Neto, José M. Alves, Anne K. de Abreu Galvão, José G. F. M. da Silva, Juliane S. de França Rodrigues-Mascarenhas, Sandra Front Physiol Physiology Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormone and adrenal cortex is its main source. Direct effects of ouabain are originated due to the binding to its receptor, the Na(+)/K(+)-ATPase, on target cells. This interaction can promote Na(+) transport blockade or even activation of signaling transduction pathways (e.g., EGFR/Src-Ras-ERK pathway activation), independent of ion transport. Besides the well-known effect of ouabain on the cardiovascular system and blood pressure control, compelling evidence indicates that ouabain regulates a number of immune functions. Inflammation is a tightly coordinated immunological function that is also affected by ouabain. Indeed, this hormone can modulate many inflammatory events such as cell migration, vascular permeability, and cytokine production. Moreover, ouabain also interferes on neuroinflammation. However, it is not clear how ouabain controls these events. In this brief review, we summarize the updates of ouabain effect on several aspects of peripheral and central inflammation, bringing new insights into ouabain functions on the immune system. Frontiers Media S.A. 2017-11-10 /pmc/articles/PMC5686084/ /pubmed/29176951 http://dx.doi.org/10.3389/fphys.2017.00895 Text en Copyright © 2017 Cavalcante-Silva, Lima, Carvalho, Sales-Neto, Alves, Galvão, Silva and Rodrigues-Mascarenhas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Cavalcante-Silva, Luiz H. A.
Lima, Éssia de Almeida
Carvalho, Deyse C. M.
de Sales-Neto, José M.
Alves, Anne K. de Abreu
Galvão, José G. F. M.
da Silva, Juliane S. de França
Rodrigues-Mascarenhas, Sandra
Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
title Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
title_full Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
title_fullStr Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
title_full_unstemmed Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
title_short Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
title_sort much more than a cardiotonic steroid: modulation of inflammation by ouabain
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686084/
https://www.ncbi.nlm.nih.gov/pubmed/29176951
http://dx.doi.org/10.3389/fphys.2017.00895
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