TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation

Induced pluripotent stem cells (iPSCs) are suitable for studying mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations. Here, we generated iPSCs from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with the m.13513G>A mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Yahata, Naoki, Matsumoto, Yuji, Omi, Minoru, Yamamoto, Naoki, Hata, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686150/
https://www.ncbi.nlm.nih.gov/pubmed/29138463
http://dx.doi.org/10.1038/s41598-017-15871-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686150/
https://www.ncbi.nlm.nih.gov/pubmed/29138463
http://dx.doi.org/10.1038/s41598-017-15871-y

Ejemplares similares