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α subunits in GABA(A) receptors are dispensable for GABA and diazepam action

The major isoform of the GABA(A) receptor is α(1)β(2)γ(2). The binding sites for the agonist GABA are located at the β(2)+/α(1)− subunit interfaces and the modulatory site for benzodiazepines at α(1)+/γ(2)−. In the absence of α(1) subunits, a receptor was formed that was gated by GABA and modulated...

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Detalles Bibliográficos
Autores principales: Wongsamitkul, Nisa, Maldifassi, Maria C., Simeone, Xenia, Baur, Roland, Ernst, Margot, Sigel, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686171/
https://www.ncbi.nlm.nih.gov/pubmed/29138471
http://dx.doi.org/10.1038/s41598-017-15628-7

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