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Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis

This systematic review aims to assess the efficacy of titanium (Ti) implant surfaces with or without strontium (Sr) incorporation on osseointegration in animal experimental studies. An electronic search was conducted using databases of PubMed and EMBASE up to November 2016 to identify studies focusi...

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Autores principales: Shi, Junyu, Li, Yuan, Gu, Yingxin, Qiao, Shichong, Zhang, Xiaomeng, Lai, Hongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686172/
https://www.ncbi.nlm.nih.gov/pubmed/29138499
http://dx.doi.org/10.1038/s41598-017-15488-1
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author Shi, Junyu
Li, Yuan
Gu, Yingxin
Qiao, Shichong
Zhang, Xiaomeng
Lai, Hongchang
author_facet Shi, Junyu
Li, Yuan
Gu, Yingxin
Qiao, Shichong
Zhang, Xiaomeng
Lai, Hongchang
author_sort Shi, Junyu
collection PubMed
description This systematic review aims to assess the efficacy of titanium (Ti) implant surfaces with or without strontium (Sr) incorporation on osseointegration in animal experimental studies. An electronic search was conducted using databases of PubMed and EMBASE up to November 2016 to identify studies focusing on osseointegration of strontium-modified titanium implants following PRISMA criteria. The primary outcome was the percentage of bone-to-implant contact (BIC) around the implants with or without strontium-modified surface. Of the 1320 studies, 17 studies fulfilling the inclusion criteria were finally included. A random effect meta-analysis was conducted based on BIC in 17 studies, and the results demonstrated considerable heterogeneity (I² = 79%). A sensitivity analysis found that three studies using the same surface modification method were the major source of the heterogeneity. Therefore, exploratory subgroup analysis was performed. Subgroup one including 14 studies showed a standard mean differences (SMD) of 1.42 (95% CI, 1.13–1.71) with no heterogeneity (I² = 0.0%), while subgroup two including the other three studies showed a SMD of 9.49.95% CI, 7.51–11.47) with low heterogeneity (I² = 0.1%). Sr-modified implants in both subgroups showed significantly higher BIC than unmodified implants (P < 0.01). The results showed a statistically significant effect of Sr-modified titanium implant surfaces on osseointegration and bone apposition in animal models.
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spelling pubmed-56861722017-11-21 Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis Shi, Junyu Li, Yuan Gu, Yingxin Qiao, Shichong Zhang, Xiaomeng Lai, Hongchang Sci Rep Article This systematic review aims to assess the efficacy of titanium (Ti) implant surfaces with or without strontium (Sr) incorporation on osseointegration in animal experimental studies. An electronic search was conducted using databases of PubMed and EMBASE up to November 2016 to identify studies focusing on osseointegration of strontium-modified titanium implants following PRISMA criteria. The primary outcome was the percentage of bone-to-implant contact (BIC) around the implants with or without strontium-modified surface. Of the 1320 studies, 17 studies fulfilling the inclusion criteria were finally included. A random effect meta-analysis was conducted based on BIC in 17 studies, and the results demonstrated considerable heterogeneity (I² = 79%). A sensitivity analysis found that three studies using the same surface modification method were the major source of the heterogeneity. Therefore, exploratory subgroup analysis was performed. Subgroup one including 14 studies showed a standard mean differences (SMD) of 1.42 (95% CI, 1.13–1.71) with no heterogeneity (I² = 0.0%), while subgroup two including the other three studies showed a SMD of 9.49.95% CI, 7.51–11.47) with low heterogeneity (I² = 0.1%). Sr-modified implants in both subgroups showed significantly higher BIC than unmodified implants (P < 0.01). The results showed a statistically significant effect of Sr-modified titanium implant surfaces on osseointegration and bone apposition in animal models. Nature Publishing Group UK 2017-11-14 /pmc/articles/PMC5686172/ /pubmed/29138499 http://dx.doi.org/10.1038/s41598-017-15488-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Shi, Junyu
Li, Yuan
Gu, Yingxin
Qiao, Shichong
Zhang, Xiaomeng
Lai, Hongchang
Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis
title Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis
title_full Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis
title_fullStr Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis
title_full_unstemmed Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis
title_short Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis
title_sort effect of titanium implants with strontium incorporation on bone apposition in animal models: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686172/
https://www.ncbi.nlm.nih.gov/pubmed/29138499
http://dx.doi.org/10.1038/s41598-017-15488-1
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