IVIG activates FcγRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice

Following intracerebral hemorrhage (ICH), the activation of mast cell contributes to brain inflammation and brain injury. The mast cell activation is negatively regulated by an inhibitory IgG-receptor. It’s signals are mediated by SHIP (Src homology 2-containing inositol 5′ phosphatase), in particul...

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Detalles Bibliográficos
Autores principales: Akyol, Gokce Yilmaz, Manaenko, Anatol, Akyol, Onat, Solaroglu, Ihsan, Ho, Wing Mann, Ding, Yan, Flores, Jerry, Zhang, John H., Tang, Jiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686215/
https://www.ncbi.nlm.nih.gov/pubmed/29138419
http://dx.doi.org/10.1038/s41598-017-15455-w

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