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Deletion of Nedd4-2 results in progressive kidney disease in mice

NEDD4-2 (NEDD4L), a ubiquitin protein ligase of the Nedd4 family, is a key regulator of cell surface expression and activity of the amiloride-sensitive epithelial Na(+) channel (ENaC). While hypomorphic alleles of Nedd4-2 in mice show salt-sensitive hypertension, complete knockout results in pulmona...

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Detalles Bibliográficos
Autores principales:	Henshall, Tanya L, Manning, Jantina A, Alfassy, Omri S, Goel, Pranay, Boase, Natasha A, Kawabe, Hiroshi, Kumar, Sharad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686353/ https://www.ncbi.nlm.nih.gov/pubmed/28862701 http://dx.doi.org/10.1038/cdd.2017.137

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