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iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity

Developing lymphocytes express the recombination activating genes (RAGs) 1 and 2 products that form a site specific recombinase complex (RAG), introducing double strand DNA breaks (DSBs) at recombination signal sequences (RSSs) flanking the V, D, and J gene segments in the antigen receptor loci. The...

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Detalles Bibliográficos
Autores principales:	Bonnet, Marie, Sarmento, Leonor Morais, Martins, Ana C., Sobral, Daniel, Silva, Joana, Demengeot, Jocelyne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686385/ https://www.ncbi.nlm.nih.gov/pubmed/29176980 http://dx.doi.org/10.3389/fimmu.2017.01525

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