Cargando…

Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study

CONTEXT: Little is known about the association between obesity and temporal trends in the incidence of diabetes in children and young adults. OBJECTIVE: We examined the recent incidence of types 1 and 2 diabetes in relation to a high body mass index (BMI) in UK children and young adults. DESIGN: Coh...

Descripción completa

Detalles Bibliográficos
Autores principales: Abbasi, Ali, Juszczyk, Dorota, van Jaarsveld, Cornelia H. M., Gulliford, Martin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686575/
https://www.ncbi.nlm.nih.gov/pubmed/29264507
http://dx.doi.org/10.1210/js.2017-00044
_version_ 1783278804126400512
author Abbasi, Ali
Juszczyk, Dorota
van Jaarsveld, Cornelia H. M.
Gulliford, Martin C.
author_facet Abbasi, Ali
Juszczyk, Dorota
van Jaarsveld, Cornelia H. M.
Gulliford, Martin C.
author_sort Abbasi, Ali
collection PubMed
description CONTEXT: Little is known about the association between obesity and temporal trends in the incidence of diabetes in children and young adults. OBJECTIVE: We examined the recent incidence of types 1 and 2 diabetes in relation to a high body mass index (BMI) in UK children and young adults. DESIGN: Cohort and nested case-control. SETTING: A total of 375 general practices that contribute to the UK Clinical Practice Research Datalink (CPRD). PARTICIPANTS: A total of 369,362 participants aged 2 to 15 years at BMI measurement in CPRD from 1994 to 2013. INTERVENTION: None. MAIN OUTCOME MEASURES: Incident type 1 diabetes (T1D) and type 2 diabetes (T2D) diagnoses up to age 25 years. RESULTS: A total of 654 incident cases of T2D and 1318 T1D cases were found. The incidence of T2D per 100,000 persons annually increased from 6.4 in 1994 to 1998 to 33.2 in 2009 to 2013; and that for T1D increased from 38.2 to 52.1 per 100,000 persons during the same period. The incidence of T2D increased in both overweight (85th to 95th percentile for age- and sex-specific BMI; P = 0.01) and obese (≥95th percentile; P < 0.01) individuals from 1994 to 2013. Obese individuals, who constituted 47.1% of T2D cases, had a markedly greater risk of incident T2D [odds ratio, 3.75; 95% confidence interval (CI), 3.07 to 4.57], with an incidence rate ratio of 4.33 (95% CI, 3.68 to 5.08) compared with the normal BMI category. No positive linear association was found between obesity (greater BMI) and incident T1D cases. CONCLUSIONS: Increasing obesity has contributed to the increasing incidence of T2D but not T1D among UK children and young adults, with a fourfold greater risk of developing T2D in obese individuals.
format Online
Article
Text
id pubmed-5686575
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Endocrine Society
record_format MEDLINE/PubMed
spelling pubmed-56865752017-12-20 Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study Abbasi, Ali Juszczyk, Dorota van Jaarsveld, Cornelia H. M. Gulliford, Martin C. J Endocr Soc Clinical Research Articles CONTEXT: Little is known about the association between obesity and temporal trends in the incidence of diabetes in children and young adults. OBJECTIVE: We examined the recent incidence of types 1 and 2 diabetes in relation to a high body mass index (BMI) in UK children and young adults. DESIGN: Cohort and nested case-control. SETTING: A total of 375 general practices that contribute to the UK Clinical Practice Research Datalink (CPRD). PARTICIPANTS: A total of 369,362 participants aged 2 to 15 years at BMI measurement in CPRD from 1994 to 2013. INTERVENTION: None. MAIN OUTCOME MEASURES: Incident type 1 diabetes (T1D) and type 2 diabetes (T2D) diagnoses up to age 25 years. RESULTS: A total of 654 incident cases of T2D and 1318 T1D cases were found. The incidence of T2D per 100,000 persons annually increased from 6.4 in 1994 to 1998 to 33.2 in 2009 to 2013; and that for T1D increased from 38.2 to 52.1 per 100,000 persons during the same period. The incidence of T2D increased in both overweight (85th to 95th percentile for age- and sex-specific BMI; P = 0.01) and obese (≥95th percentile; P < 0.01) individuals from 1994 to 2013. Obese individuals, who constituted 47.1% of T2D cases, had a markedly greater risk of incident T2D [odds ratio, 3.75; 95% confidence interval (CI), 3.07 to 4.57], with an incidence rate ratio of 4.33 (95% CI, 3.68 to 5.08) compared with the normal BMI category. No positive linear association was found between obesity (greater BMI) and incident T1D cases. CONCLUSIONS: Increasing obesity has contributed to the increasing incidence of T2D but not T1D among UK children and young adults, with a fourfold greater risk of developing T2D in obese individuals. Endocrine Society 2017-04-25 /pmc/articles/PMC5686575/ /pubmed/29264507 http://dx.doi.org/10.1210/js.2017-00044 Text en Copyright © 2017 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research Articles
Abbasi, Ali
Juszczyk, Dorota
van Jaarsveld, Cornelia H. M.
Gulliford, Martin C.
Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study
title Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study
title_full Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study
title_fullStr Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study
title_full_unstemmed Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study
title_short Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study
title_sort body mass index and incident type 1 and type 2 diabetes in children and young adults: a retrospective cohort study
topic Clinical Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686575/
https://www.ncbi.nlm.nih.gov/pubmed/29264507
http://dx.doi.org/10.1210/js.2017-00044
work_keys_str_mv AT abbasiali bodymassindexandincidenttype1andtype2diabetesinchildrenandyoungadultsaretrospectivecohortstudy
AT juszczykdorota bodymassindexandincidenttype1andtype2diabetesinchildrenandyoungadultsaretrospectivecohortstudy
AT vanjaarsveldcorneliahm bodymassindexandincidenttype1andtype2diabetesinchildrenandyoungadultsaretrospectivecohortstudy
AT gullifordmartinc bodymassindexandincidenttype1andtype2diabetesinchildrenandyoungadultsaretrospectivecohortstudy