Cargando…

High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

CONTEXT: Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with first recognition during pregnancy, is a heterogeneous form of diabetes characterized by various degrees of β-cell dysfunction. OBJECTIVES: We aimed to estimate the prevalence of possibly pathogenic varia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gjesing, Anette P., Rui, Gao, Lauenborg, Jeannet, Have, Christian Theil, Hollensted, Mette, Andersson, Ehm, Grarup, Niels, Sun, Jihua, Quan, Shi, Brandslund, Ivan, Damm, Peter, Pedersen, Oluf, Wang, Jun, Hansen, Torben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686663/ https://www.ncbi.nlm.nih.gov/pubmed/29264522 http://dx.doi.org/10.1210/js.2017-00040

Ejemplares similares

Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes
por: Niazi, Robina Khan, et al.
Publicado: (2019)

Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants
por: Sun, Jihua, et al.
Publicado: (2019)

Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
por: Boesgaard, Trine W, et al.
Publicado: (2010)

Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity
por: Niazi, Robina Khan, et al.
Publicado: (2018)

The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals
por: Banasik, Karina, et al.
Publicado: (2012)

Screening of 31 genes involved in monogenic forms of obesity in 23 Pakistani probands with early-onset childhood obesity: a case report
por: Niazi, Robina Khan, et al.
Publicado: (2019)

Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study
por: Hollensted, Mette, et al.
Publicado: (2018)

Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model
por: Gao, Rui, et al.
Publicado: (2014)

A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents
por: Nielsen, Tenna Ruest Haarmark, et al.
Publicado: (2017)

Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum
por: Crusell, Mie K. W., et al.
Publicado: (2020)

Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations
por: Trier, Cæcilie, et al.
Publicado: (2020)

The Type 2 Diabetes Risk Allele of TMEM154-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes
por: Harder, Marie Neergaard, et al.
Publicado: (2015)

Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes
por: Gjesing, Anette P, et al.
Publicado: (2011)

Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case–control study
por: Hollensted, Mette, et al.
Publicado: (2015)

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report
por: Iepsen, Eva W., et al.
Publicado: (2020)

Do Gene Variants Influencing Adult Adiposity Affect Birth Weight? A Population-Based Study of 24 Loci in 4,744 Danish Individuals
por: Andersson, Ehm A., et al.
Publicado: (2010)

Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes
por: Hansen, Tue H, et al.
Publicado: (2015)

(1)H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents
por: Fonvig, Cilius Esmann, et al.
Publicado: (2015)

Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes
por: Crusell, Mie Korslund Wiinblad, et al.
Publicado: (2020)

Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum
por: Crusell, Mie Korslund Wiinblad, et al.
Publicado: (2018)

Variant near ADAMTS9 Known to Associate with Type 2 Diabetes Is Related to Insulin Resistance in Offspring of Type 2 Diabetes Patients—EUGENE2 Study
por: Boesgaard, Trine Welløv, et al.
Publicado: (2009)

Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes
por: Thomsen, Stine B., et al.
Publicado: (2015)

Long-Term Follow-Up on Morbidity Among Women With a History of Gestational Diabetes Mellitus: A Systematic Review
por: Flachs Madsen, Lana R, et al.
Publicado: (2022)

Vejle Diabetes Biobank – a resource for studies of the etiologies of diabetes and its comorbidities
por: Petersen, Eva Rabing Brix, et al.
Publicado: (2016)

Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population
por: Li, Shengting, et al.
Publicado: (2014)

Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?
por: Gillberg, Linn, et al.
Publicado: (2013)

Correction: Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?
por: Gillberg, Linn, et al.
Publicado: (2013)

Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes
por: Snogdal, Lena Sønder, et al.
Publicado: (2013)

Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations
por: Borisevich, Dmitrii, et al.
Publicado: (2021)

An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese
por: Graae, Anne-Sofie, et al.
Publicado: (2018)

No Consistent Effect of ADRB2 Haplotypes on Obesity, Hypertension and Quantitative Traits of Body Fatness and Blood Pressure among 6,514 Adult Danes
por: Gjesing, Anette P., et al.
Publicado: (2009)

G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans
por: Sparsø, Thomas, et al.
Publicado: (2009)

The Effect of PCSK1 Variants on Waist, Waist-Hip Ratio and Glucose Metabolism Is Modified by Sex and Glucose Tolerance Status
por: Gjesing, Anette P., et al.
Publicado: (2011)

Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants
por: Borglykke, Anders, et al.
Publicado: (2012)

Correction: Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease – Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants
por: Borglykke, Anders, et al.
Publicado: (2013)

Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology
por: Schnurr, Theresia M., et al.
Publicado: (2016)

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
por: Andreasen, Camilla Helene, et al.
Publicado: (2008)

A Combined Analysis of 48 Type 2 Diabetes Genetic Risk Variants Shows No Discriminative Value to Predict Time to First Prescription of a Glucose Lowering Drug in Danish Patients with Screen Detected Type 2 Diabetes
por: Hornbak, Malene, et al.
Publicado: (2014)

A suppressor locus for MODY3-diabetes
por: Garcia-Gonzalez, Miguel A., et al.
Publicado: (2016)

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
por: Bacos, Karl, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_094n6clu6f7l4ccac32rd9cbrb