A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report

Congenital adrenal hyperplasia (CAH) can affect sex characteristics. The most common cause of CAH is 21-hydroxylase deficiency, and the cornerstone of treatment is glucocorticoid replacement in adrenocorticotropic hormone-suppressive dosages. A 64-year-old patient (46XX) with CAH resulting from 21-h...

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Detalles Bibliográficos
Autores principales: Wesselius, Ruben, Schotman, Mirjam, Schotman, Martje, Pereira, Alberto M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686766/
https://www.ncbi.nlm.nih.gov/pubmed/29264577
http://dx.doi.org/10.1210/js.2017-00281
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author Wesselius, Ruben
Schotman, Mirjam
Schotman, Martje
Pereira, Alberto M.
author_facet Wesselius, Ruben
Schotman, Mirjam
Schotman, Martje
Pereira, Alberto M.
author_sort Wesselius, Ruben
collection PubMed
description Congenital adrenal hyperplasia (CAH) can affect sex characteristics. The most common cause of CAH is 21-hydroxylase deficiency, and the cornerstone of treatment is glucocorticoid replacement in adrenocorticotropic hormone-suppressive dosages. A 64-year-old patient (46XX) with CAH resulting from 21-hydroxylase deficiency had been treated with dexamethasone and testosterone since diagnosis at age 12 and was phenotypically male. At age 62, he was diagnosed with prostate carcinoma. The patient received curative treatment with external beam radiotherapy. Genotypically female patients with CAH can develop prostate carcinoma when receiving long-term testosterone replacement therapy.
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spelling pubmed-56867662017-12-20 A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report Wesselius, Ruben Schotman, Mirjam Schotman, Martje Pereira, Alberto M. J Endocr Soc Case Reports Congenital adrenal hyperplasia (CAH) can affect sex characteristics. The most common cause of CAH is 21-hydroxylase deficiency, and the cornerstone of treatment is glucocorticoid replacement in adrenocorticotropic hormone-suppressive dosages. A 64-year-old patient (46XX) with CAH resulting from 21-hydroxylase deficiency had been treated with dexamethasone and testosterone since diagnosis at age 12 and was phenotypically male. At age 62, he was diagnosed with prostate carcinoma. The patient received curative treatment with external beam radiotherapy. Genotypically female patients with CAH can develop prostate carcinoma when receiving long-term testosterone replacement therapy. Endocrine Society 2017-08-17 /pmc/articles/PMC5686766/ /pubmed/29264577 http://dx.doi.org/10.1210/js.2017-00281 Text en Copyright © 2017 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Reports
Wesselius, Ruben
Schotman, Mirjam
Schotman, Martje
Pereira, Alberto M.
A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report
title A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report
title_full A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report
title_fullStr A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report
title_full_unstemmed A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report
title_short A Patient (46XX) With Congenital Adrenal Hyperplasia and Prostate Cancer: A Case Report
title_sort patient (46xx) with congenital adrenal hyperplasia and prostate cancer: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686766/
https://www.ncbi.nlm.nih.gov/pubmed/29264577
http://dx.doi.org/10.1210/js.2017-00281
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