Differential Effects of Estrogen on Corticosteroid-Binding Globulin Forms Suggests Reduced Cleavage in Pregnancy

Corticosteroid-binding globulin (CBG) is secreted as high-affinity CBG (haCBG), which may be cleaved by tissue proteases to low-affinity CBG (laCBG), releasing free cortisol. Pregnancy and the estrogen-based combined oral contraceptive pill (COCP) increase CBG concentrations twofold to threefold. Th...

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Detalles Bibliográficos
Autores principales: Nenke, Marni A., Zeng, Anna, Meyer, Emily J., Lewis, John G., Rankin, Wayne, Johnston, Julie, Kireta, Svjetlana, Jesudason, Shilpanjali, Torpy, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2017
Materias:
Clinical Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686768/
https://www.ncbi.nlm.nih.gov/pubmed/29264477
http://dx.doi.org/10.1210/js.2016-1094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686768/
https://www.ncbi.nlm.nih.gov/pubmed/29264477
http://dx.doi.org/10.1210/js.2016-1094

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