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Conformational Change in the Ligand-Binding Pocket via a KISS1R Mutation (P147L) Leads to Isolated Gonadotropin-Releasing Hormone Deficiency

CONTEXT: Kisspeptin receptor (KISS1R) is expressed in hypothalamic gonadotropin-releasing hormone neurons and responsible for pubertal onset and reproductive functions. KISS1R mutations remain a rare cause of congenital hypogonadotropic hypogonadism (CHH). OBJECTIVE: The aim of this study was to ide...

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Detalles Bibliográficos
Autores principales:	Shimizu, Koichiro, Yonekawa, Tadato, Yoshida, Morikatsu, Miyazato, Mikiya, Miura, Ayako, Sakoda, Hideyuki, Yamaguchi, Hideki, Nakazato, Masamitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2017
Materias:	Clinical Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686787/ https://www.ncbi.nlm.nih.gov/pubmed/29264451 http://dx.doi.org/10.1210/js.2017-00277

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