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Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase

Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions. PEGylation has become a sophisticated method to decrease that immunogenicity. In this report, according predicted epitope...

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Detalles Bibliográficos
Autores principales:	Xu, Yanying, Shi, Yueyuan, Zhou, Jianzhong, Yang, Wei, Bai, Lei, Wang, Shilei, Jin, Xin, Niu, Qiangsi, Huang, Ailong, Wang, Deqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686944/ https://www.ncbi.nlm.nih.gov/pubmed/29137636 http://dx.doi.org/10.1186/s12934-017-0801-y

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