Physiogenomics in Etiopathogenesis of Cholangiocarcinoma

OBJECTIVE: Cholangiocarcinoma is a serious malignancy that is very common in the tropical countries. It is a kind of deadly primary hepatobiliary tumor. There is a wide spectrum of tumors with varying differentiation and malignancy grades. Although it has been known for a long time inmmedicine, there is no clear cut that this deadly cancer is genetic disorder or not. A systemic approach on the pathophysiology and genomics can provide useful information and help better understand the pathogenesis of cholangiocarcinoma. METHODS: In this work, a standard bioinformatics physiological genomics analysis of cholangiocarcinoma was performed. RESULT: According to this work, there is no identified physiogenomics relationship for the cholangiocarcinoma. CONCLUSION: This might imply that the cholangiocarcinoma is directly due to environmental insult. It implies that there should be no specific gene that might contribute to the increased risk in the etiopathogenesis of cholangiocarcinoma.