Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity

The synthesis of diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside is presented for the first time. This synthetic saponin was transformed into its hydrochloride as well as N-acyl, 2-ureido, N-alkyl, and N,N-dialkyl derivatives. Antifungal and antibacterial studies show that some of the obtained compo...

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Autores principales: Myszka, Henryk, Sokołowska, Patrycja, Cieślińska, Agnieszka, Nowacki, Andrzej, Jaśkiewicz, Maciej, Kamysz, Wojciech, Liberek, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687012/
https://www.ncbi.nlm.nih.gov/pubmed/29181110
http://dx.doi.org/10.3762/bjoc.13.227
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author Myszka, Henryk
Sokołowska, Patrycja
Cieślińska, Agnieszka
Nowacki, Andrzej
Jaśkiewicz, Maciej
Kamysz, Wojciech
Liberek, Beata
author_facet Myszka, Henryk
Sokołowska, Patrycja
Cieślińska, Agnieszka
Nowacki, Andrzej
Jaśkiewicz, Maciej
Kamysz, Wojciech
Liberek, Beata
author_sort Myszka, Henryk
collection PubMed
description The synthesis of diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside is presented for the first time. This synthetic saponin was transformed into its hydrochloride as well as N-acyl, 2-ureido, N-alkyl, and N,N-dialkyl derivatives. Antifungal and antibacterial studies show that some of the obtained compounds are active against Gram-positive bacteria and Candida type fungi.
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spelling pubmed-56870122017-11-27 Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity Myszka, Henryk Sokołowska, Patrycja Cieślińska, Agnieszka Nowacki, Andrzej Jaśkiewicz, Maciej Kamysz, Wojciech Liberek, Beata Beilstein J Org Chem Full Research Paper The synthesis of diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside is presented for the first time. This synthetic saponin was transformed into its hydrochloride as well as N-acyl, 2-ureido, N-alkyl, and N,N-dialkyl derivatives. Antifungal and antibacterial studies show that some of the obtained compounds are active against Gram-positive bacteria and Candida type fungi. Beilstein-Institut 2017-11-01 /pmc/articles/PMC5687012/ /pubmed/29181110 http://dx.doi.org/10.3762/bjoc.13.227 Text en Copyright © 2017, Myszka et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Myszka, Henryk
Sokołowska, Patrycja
Cieślińska, Agnieszka
Nowacki, Andrzej
Jaśkiewicz, Maciej
Kamysz, Wojciech
Liberek, Beata
Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
title Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
title_full Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
title_fullStr Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
title_full_unstemmed Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
title_short Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
title_sort diosgenyl 2-amino-2-deoxy-β-d-galactopyranoside: synthesis, derivatives and antimicrobial activity
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687012/
https://www.ncbi.nlm.nih.gov/pubmed/29181110
http://dx.doi.org/10.3762/bjoc.13.227
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