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Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces are organized in an anisotropic manner to p...

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Detalles Bibliográficos
Autores principales: De Simone, Alessandro, Gönczy, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687019/
https://www.ncbi.nlm.nih.gov/pubmed/28701341
http://dx.doi.org/10.1091/mbc.E16-12-0823

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