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Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers

The development of drug resistance in cancer poses a major clinical problem. An example is human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer often treated with anti-HER2 antibody therapies, such as trastuzumab. Because drug resistance is rooted mainly in tumor cell heterog...

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Detalles Bibliográficos
Autores principales: Peckys, Diana B., Korf, Ulrike, Wiemann, Stefan, de Jonge, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687022/
https://www.ncbi.nlm.nih.gov/pubmed/28794264
http://dx.doi.org/10.1091/mbc.E17-06-0381

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