Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence

A study exploring the chemical behavior of some dihydroxylated β-amino ester stereo- and regioisomers, derived from unsaturated cyclic β-amino acids is described. The nucleophilic fluorinations involving hydroxy–fluorine exchange of some highly functionalized alicyclic diol derivatives have been car...

Descripción completa

Detalles Bibliográficos
Autores principales: Remete, Attila Márió, Nonn, Melinda, Fustero, Santos, Haukka, Matti, Fülöp, Ferenc, Kiss, Loránd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687045/
https://www.ncbi.nlm.nih.gov/pubmed/29181116
http://dx.doi.org/10.3762/bjoc.13.233
_version_ 1783278898009604096
author Remete, Attila Márió
Nonn, Melinda
Fustero, Santos
Haukka, Matti
Fülöp, Ferenc
Kiss, Loránd
author_facet Remete, Attila Márió
Nonn, Melinda
Fustero, Santos
Haukka, Matti
Fülöp, Ferenc
Kiss, Loránd
author_sort Remete, Attila Márió
collection PubMed
description A study exploring the chemical behavior of some dihydroxylated β-amino ester stereo- and regioisomers, derived from unsaturated cyclic β-amino acids is described. The nucleophilic fluorinations involving hydroxy–fluorine exchange of some highly functionalized alicyclic diol derivatives have been carried out in view of selective fluorination, investigating substrate dependence, neighboring group assistance and chemodifferentiation.
format Online
Article
Text
id pubmed-5687045
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-56870452017-11-27 Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence Remete, Attila Márió Nonn, Melinda Fustero, Santos Haukka, Matti Fülöp, Ferenc Kiss, Loránd Beilstein J Org Chem Full Research Paper A study exploring the chemical behavior of some dihydroxylated β-amino ester stereo- and regioisomers, derived from unsaturated cyclic β-amino acids is described. The nucleophilic fluorinations involving hydroxy–fluorine exchange of some highly functionalized alicyclic diol derivatives have been carried out in view of selective fluorination, investigating substrate dependence, neighboring group assistance and chemodifferentiation. Beilstein-Institut 2017-11-06 /pmc/articles/PMC5687045/ /pubmed/29181116 http://dx.doi.org/10.3762/bjoc.13.233 Text en Copyright © 2017, Remete et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Remete, Attila Márió
Nonn, Melinda
Fustero, Santos
Haukka, Matti
Fülöp, Ferenc
Kiss, Loránd
Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
title Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
title_full Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
title_fullStr Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
title_full_unstemmed Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
title_short Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
title_sort fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687045/
https://www.ncbi.nlm.nih.gov/pubmed/29181116
http://dx.doi.org/10.3762/bjoc.13.233
work_keys_str_mv AT remeteattilamario fluorinationofsomehighlyfunctionalizedcycloalkaneschemoselectivityandsubstratedependence
AT nonnmelinda fluorinationofsomehighlyfunctionalizedcycloalkaneschemoselectivityandsubstratedependence
AT fusterosantos fluorinationofsomehighlyfunctionalizedcycloalkaneschemoselectivityandsubstratedependence
AT haukkamatti fluorinationofsomehighlyfunctionalizedcycloalkaneschemoselectivityandsubstratedependence
AT fulopferenc fluorinationofsomehighlyfunctionalizedcycloalkaneschemoselectivityandsubstratedependence
AT kisslorand fluorinationofsomehighlyfunctionalizedcycloalkaneschemoselectivityandsubstratedependence

Ejemplares similares