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Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced Cardiotoxicity

BACKGROUND: Anthracyclines-induced cardiotoxicity has become one of the major restrictions of their clinical applications. Klotho showed cardioprotective effects. This study aimed to investigate the effects and possible mechanisms of klotho on doxorubicin (DOX)-induced cardiotoxicity. MATERIAL/METHO...

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Detalles Bibliográficos
Autores principales:	Zhu, Huolan, Gao, Yan, Zhu, Shunming, Cui, Qianwei, Du, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2017
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687120/ https://www.ncbi.nlm.nih.gov/pubmed/29107939 http://dx.doi.org/10.12659/MSM.907449

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