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Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis

The objective of this study was to examine the relationship between adipokines and adiposity in individuals with rheumatoid and osteoarthritis in the Atlantic PATH cohort. Using a nested case-control analysis, participants in the Atlantic PATH cohort with rheumatoid or osteoarthritis were matched fo...

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Autores principales: DeClercq, Vanessa, Cui, Yunsong, Forbes, Cynthia, Grandy, Scott A., Keats, Melanie, Parker, Louise, Sweeney, Ellen, Yu, Zhijie Michael, Dummer, Trevor J. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687138/
https://www.ncbi.nlm.nih.gov/pubmed/29225423
http://dx.doi.org/10.1155/2017/4302412
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author DeClercq, Vanessa
Cui, Yunsong
Forbes, Cynthia
Grandy, Scott A.
Keats, Melanie
Parker, Louise
Sweeney, Ellen
Yu, Zhijie Michael
Dummer, Trevor J. B.
author_facet DeClercq, Vanessa
Cui, Yunsong
Forbes, Cynthia
Grandy, Scott A.
Keats, Melanie
Parker, Louise
Sweeney, Ellen
Yu, Zhijie Michael
Dummer, Trevor J. B.
author_sort DeClercq, Vanessa
collection PubMed
description The objective of this study was to examine the relationship between adipokines and adiposity in individuals with rheumatoid and osteoarthritis in the Atlantic PATH cohort. Using a nested case-control analysis, participants in the Atlantic PATH cohort with rheumatoid or osteoarthritis were matched for measures of adiposity with participants without a history of arthritis. Both measured and self-reported data were used to examine disease status, adiposity, and lifestyle factors. Immunoassays were used to measure plasma markers. BMI was positively correlated with percentage body fat, fat mass index (FMI), and a change in BMI from 18 years of age in all 3 groups. There were no statistical differences between levels of plasma adipokines; adiponectin levels were 6.6, 7.9, and 8.2 μg/ml, leptin levels were 10.3, 13.7, and 11.5 ng/ml, and resistin levels were 10.0, 12.1, and 10.8 ng/ml in participants without arthritis, with rheumatoid arthritis, and with osteoarthritis, respectively. Those with higher levels of adiponectin were more likely to have osteoarthritis (but not rheumatoid arthritis). No association was found between arthritis types and leptin or resistin. This study demonstrates differences in measures of adiposity and adipokines in specific types of arthritis and highlights the need for more research targeting specific adipokines during arthritic disease progression.
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spelling pubmed-56871382017-12-10 Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis DeClercq, Vanessa Cui, Yunsong Forbes, Cynthia Grandy, Scott A. Keats, Melanie Parker, Louise Sweeney, Ellen Yu, Zhijie Michael Dummer, Trevor J. B. Mediators Inflamm Research Article The objective of this study was to examine the relationship between adipokines and adiposity in individuals with rheumatoid and osteoarthritis in the Atlantic PATH cohort. Using a nested case-control analysis, participants in the Atlantic PATH cohort with rheumatoid or osteoarthritis were matched for measures of adiposity with participants without a history of arthritis. Both measured and self-reported data were used to examine disease status, adiposity, and lifestyle factors. Immunoassays were used to measure plasma markers. BMI was positively correlated with percentage body fat, fat mass index (FMI), and a change in BMI from 18 years of age in all 3 groups. There were no statistical differences between levels of plasma adipokines; adiponectin levels were 6.6, 7.9, and 8.2 μg/ml, leptin levels were 10.3, 13.7, and 11.5 ng/ml, and resistin levels were 10.0, 12.1, and 10.8 ng/ml in participants without arthritis, with rheumatoid arthritis, and with osteoarthritis, respectively. Those with higher levels of adiponectin were more likely to have osteoarthritis (but not rheumatoid arthritis). No association was found between arthritis types and leptin or resistin. This study demonstrates differences in measures of adiposity and adipokines in specific types of arthritis and highlights the need for more research targeting specific adipokines during arthritic disease progression. Hindawi 2017 2017-11-01 /pmc/articles/PMC5687138/ /pubmed/29225423 http://dx.doi.org/10.1155/2017/4302412 Text en Copyright © 2017 Vanessa DeClercq et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
DeClercq, Vanessa
Cui, Yunsong
Forbes, Cynthia
Grandy, Scott A.
Keats, Melanie
Parker, Louise
Sweeney, Ellen
Yu, Zhijie Michael
Dummer, Trevor J. B.
Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
title Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
title_full Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
title_fullStr Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
title_full_unstemmed Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
title_short Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis
title_sort adiposity measures and plasma adipokines in females with rheumatoid and osteoarthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687138/
https://www.ncbi.nlm.nih.gov/pubmed/29225423
http://dx.doi.org/10.1155/2017/4302412
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