Cargando…

SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes

Drug markets revisits herbal medicines, as historical usages address their therapeutic efficacies with less adverse effects. Moreover, herbal medicines save both cost and time in development. SH003, a modified version of traditional herbal medicine extracted from Astragalus membranaceus (Am), Angeli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Youn Kyung, Cho, Sung-Gook, Choi, Yu-Jeong, Yun, Yee Jin, Lee, Kang Min, Lee, Kangwook, Yoo, Hye-Hyun, Shin, Yong Cheol, Ko, Seong-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687613/ https://www.ncbi.nlm.nih.gov/pubmed/29179443 http://dx.doi.org/10.18632/oncotarget.11393

Ejemplares similares

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

Metabolomic Analysis of Exosomes Derived from Lung Cancer Cell Line H460 Treated with SH003 and Docetaxel
por: Choi, Yu-Jeong, et al.
Publicado: (2022)

State of the Art and Future Implications of SH003: Acting as a Therapeutic Anticancer Agent
por: Lee, Kangwook, et al.
Publicado: (2022)

SH003 and Docetaxel Show Synergistic Anticancer Effects by Inhibiting EGFR Activation in Triple-Negative Breast Cancer
por: Choi, Yu-Jeong, et al.
Publicado: (2022)

Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling
por: Choi, Youn Kyung, et al.
Publicado: (2014)

SH003 induces apoptosis of DU145 prostate cancer cells by inhibiting ERK-involved pathway
por: Choi, Yu-Jeong, et al.
Publicado: (2016)

Herbal Prescription SH003 Alleviates Docetaxel-Induced Neuropathic Pain in C57BL/6 Mice
por: Lee, Kangwook, et al.
Publicado: (2021)

Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer
por: Jeong, Mi-So, et al.
Publicado: (2021)

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice
por: Lee, Ji Hwan, et al.
Publicado: (2022)

A Phase I Study to Evaluate the Safety of the Herbal Medicine SH003 in Patients With Solid Cancer
por: Cheon, Chunhoo, et al.
Publicado: (2020)

SH003 reverses drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer cells
por: Seo, Hye-Sook, et al.
Publicado: (2017)

Phase I study to evaluate the maximum tolerated dose of the combination of SH003 and docetaxel in patients with solid cancer: A study protocol
por: Cheon, Chunhoo, et al.
Publicado: (2020)

DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
por: Dai, Anbang, et al.
Publicado: (2019)

SH003 activates autophagic cell death by activating ATF4 and inhibiting G9a under hypoxia in gastric cancer cells
por: Kim, Tae Woo, et al.
Publicado: (2020)

Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol
por: Cheon, Chunhoo, et al.
Publicado: (2018)

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
por: Hernández-Tiedra, Sonia, et al.
Publicado: (2016)

The Mixture of Natural Products SH003 Exerts Anti-Melanoma Effects through the Modulation of PD-L1 in B16F10 Cells
por: Han, Na-Ra, et al.
Publicado: (2023)

Ataxia-Telangiectasia Mutated Is Involved in Autolysosome Formation
por: Hwang, Mihwa, et al.
Publicado: (2023)

A New Herbal Formula, KSG-002, Suppresses Breast Cancer Growth and Metastasis by Targeting NF-κB-Dependent TNFα Production in Macrophages
por: Woo, Sang-Mi, et al.
Publicado: (2013)

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes
por: Boonen, Marielle, et al.
Publicado: (2011)

JNK1/2 Activation by an Extract from the Roots of Morus alba L. Reduces the Viability of Multidrug-Resistant MCF-7/Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression
por: Choi, Youn Kyung, et al.
Publicado: (2013)

Autolysosomal exocytosis of lipids protect neurons from ferroptosis
por: Ralhan, Isha, et al.
Publicado: (2023)

Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice
por: WOO, SANG-MI, et al.
Publicado: (2016)

Saussurea lappa Clarke-Derived Costunolide Prevents TNFα-Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF-κB Activity
por: Choi, Youn Kyung, et al.
Publicado: (2013)

Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
por: Kim, Nari, et al.
Publicado: (2016)

Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes
por: Bader, C. A., et al.
Publicado: (2015)

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson’s disease
por: Zucca, Fabio A., et al.
Publicado: (2018)

BAMBI Is Expressed in Endothelial Cells and Is Regulated by Lysosomal/Autolysosomal Degradation
por: Xavier, Sandhya, et al.
Publicado: (2010)

The downward spiral of tau and autolysosomes: A new hypothesis in neurodegeneration
por: Ambegaokar, Suren S., et al.
Publicado: (2012)

RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells
por: Ding, Xianming, et al.
Publicado: (2019)

Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer
por: Lou, Jian-Shu, et al.
Publicado: (2017)

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival
por: Redmann, Veronika, et al.
Publicado: (2016)

Endolysosome and Autolysosome Dysfunction in Alzheimer’s Disease: Where Intracellular and Extracellular Meet
por: van Weering, Jan R. T., et al.
Publicado: (2019)

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
por: Beillevaire, Déborah, et al.
Publicado: (2022)

Effect of Sipjeondaebo-Tang on Cancer-Induced Anorexia and Cachexia in CT-26 Tumor-Bearing Mice
por: Choi, Youn Kyung, et al.
Publicado: (2014)

Cucurbitacin D Induces G2/M Phase Arrest and Apoptosis via the ROS/p38 Pathway in Capan-1 Pancreatic Cancer Cell Line
por: Kim, Myeong-Sun, et al.
Publicado: (2020)

Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species
por: Cho, Sung-Gook, et al.
Publicado: (2014)

Topical Application of Herbal Mixture Extract Inhibits Ovalbumin- or 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis
por: Kim, Soon Re, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4bsfd7j5dkgprd7o1affhegj90