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BCRP expression in schwannoma, plexiform neurofibroma and MPNST

BACKGROUND: peripheral nerve sheath tumors comprise a broad spectrum of neoplasms. Vestibular schwannomas and plexiform neurofibromas are symptomatic albeit benign, but a subset of the latter pre-malignant lesions will transform to malignant peripheral nerve sheath tumors (MPNST). Surgery and radiot...

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Autores principales: de Vries, Maurits, van Tellingen, Olaf, van der Mey, Andel. G.L., Bunt, Antonius M.G., Bruijn, Inge Briaire-de, Hogendoorn, Pancras C.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687642/
https://www.ncbi.nlm.nih.gov/pubmed/29179472
http://dx.doi.org/10.18632/oncotarget.21075
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author de Vries, Maurits
van Tellingen, Olaf
van der Mey, Andel. G.L.
Bunt, Antonius M.G.
Bruijn, Inge Briaire-de
Hogendoorn, Pancras C.W.
author_facet de Vries, Maurits
van Tellingen, Olaf
van der Mey, Andel. G.L.
Bunt, Antonius M.G.
Bruijn, Inge Briaire-de
Hogendoorn, Pancras C.W.
author_sort de Vries, Maurits
collection PubMed
description BACKGROUND: peripheral nerve sheath tumors comprise a broad spectrum of neoplasms. Vestibular schwannomas and plexiform neurofibromas are symptomatic albeit benign, but a subset of the latter pre-malignant lesions will transform to malignant peripheral nerve sheath tumors (MPNST). Surgery and radiotherapy are the primary strategies to treat these tumors. Intrinsic resistance to drug therapy characterizes all three tumor subtypes. The breast cancer resistance protein BCRP is a transmembrane efflux transporter considered to play a key role in various biological barriers such as the blood brain barrier. At the same time it is associated with drug resistance in various tumors. Its potential role in drug resistant tumors of the peripheral nervous system is largely unknown. OBJECTIVE: to assess if BCRP is expressed in vestibular schwannomas, plexiform neurofibromas and MPNST. MATERIAL AND METHODS: immunohistochemical staining for BCRP was performed on a tissue microarray composed out of 22 vestibular schwannomas, 10 plexiform neurofibromas and 18 MPNSTs. RESULTS: sixteen out of twenty-two vestibular schwannomas (73%), nine out of ten plexiform neurofibromas (90%) and six out of eighteen MPNST (33%) expressed BCRP in the vasculature. Tumor cells were negative. CONCLUSION: BCRP is present in the vasculature of vestibular schwannomas, plexiform neurofibromas and MPSNT. Therefore, it may reduce the drug exposure of underlying tumor tissues and potentially cause failure of drug therapy.
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spelling pubmed-56876422017-11-20 BCRP expression in schwannoma, plexiform neurofibroma and MPNST de Vries, Maurits van Tellingen, Olaf van der Mey, Andel. G.L. Bunt, Antonius M.G. Bruijn, Inge Briaire-de Hogendoorn, Pancras C.W. Oncotarget Research Paper BACKGROUND: peripheral nerve sheath tumors comprise a broad spectrum of neoplasms. Vestibular schwannomas and plexiform neurofibromas are symptomatic albeit benign, but a subset of the latter pre-malignant lesions will transform to malignant peripheral nerve sheath tumors (MPNST). Surgery and radiotherapy are the primary strategies to treat these tumors. Intrinsic resistance to drug therapy characterizes all three tumor subtypes. The breast cancer resistance protein BCRP is a transmembrane efflux transporter considered to play a key role in various biological barriers such as the blood brain barrier. At the same time it is associated with drug resistance in various tumors. Its potential role in drug resistant tumors of the peripheral nervous system is largely unknown. OBJECTIVE: to assess if BCRP is expressed in vestibular schwannomas, plexiform neurofibromas and MPNST. MATERIAL AND METHODS: immunohistochemical staining for BCRP was performed on a tissue microarray composed out of 22 vestibular schwannomas, 10 plexiform neurofibromas and 18 MPNSTs. RESULTS: sixteen out of twenty-two vestibular schwannomas (73%), nine out of ten plexiform neurofibromas (90%) and six out of eighteen MPNST (33%) expressed BCRP in the vasculature. Tumor cells were negative. CONCLUSION: BCRP is present in the vasculature of vestibular schwannomas, plexiform neurofibromas and MPSNT. Therefore, it may reduce the drug exposure of underlying tumor tissues and potentially cause failure of drug therapy. Impact Journals LLC 2017-09-16 /pmc/articles/PMC5687642/ /pubmed/29179472 http://dx.doi.org/10.18632/oncotarget.21075 Text en Copyright: © 2017 de Vries et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
de Vries, Maurits
van Tellingen, Olaf
van der Mey, Andel. G.L.
Bunt, Antonius M.G.
Bruijn, Inge Briaire-de
Hogendoorn, Pancras C.W.
BCRP expression in schwannoma, plexiform neurofibroma and MPNST
title BCRP expression in schwannoma, plexiform neurofibroma and MPNST
title_full BCRP expression in schwannoma, plexiform neurofibroma and MPNST
title_fullStr BCRP expression in schwannoma, plexiform neurofibroma and MPNST
title_full_unstemmed BCRP expression in schwannoma, plexiform neurofibroma and MPNST
title_short BCRP expression in schwannoma, plexiform neurofibroma and MPNST
title_sort bcrp expression in schwannoma, plexiform neurofibroma and mpnst
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687642/
https://www.ncbi.nlm.nih.gov/pubmed/29179472
http://dx.doi.org/10.18632/oncotarget.21075
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