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hYSK1 promotes cancer cell proliferation and migration through negative regulation of p16(INK4a) under hypoxic conditions

The alteration of expression of p16(INK4a), a well-known cyclin-dependent kinase inhibitor involved in cell cycle control, in tumors is unclear, especially under hypoxic conditions. To evaluate p16(INK4a) regulation, we performed a protein microarray analysis. Among 1,800 proteins in the array, we i...

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Detalles Bibliográficos
Autores principales: Lee, Mee-Hyun, Dong, Zigang, Surh, Young-Joon, Choi, Bu Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687670/
https://www.ncbi.nlm.nih.gov/pubmed/29179500
http://dx.doi.org/10.18632/oncotarget.21654