Cargando…
Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions
Limited data is available regarding lung cancer in Chinese young adults. This study was aimed to determine the characteristics, survival, and prognostic factors of young lung cancer patients in China. We reviewed demographic and clinical data, and survival information of 420 young patients (20–45 ye...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687685/ https://www.ncbi.nlm.nih.gov/pubmed/29179515 http://dx.doi.org/10.18632/oncotarget.19183 |
_version_ | 1783279009049608192 |
---|---|
author | Li, Jianjie Yang, Fan Li, Xiao Zhang, Min Fu, Ruozi Yin, Xiaodan Wang, Jun |
author_facet | Li, Jianjie Yang, Fan Li, Xiao Zhang, Min Fu, Ruozi Yin, Xiaodan Wang, Jun |
author_sort | Li, Jianjie |
collection | PubMed |
description | Limited data is available regarding lung cancer in Chinese young adults. This study was aimed to determine the characteristics, survival, and prognostic factors of young lung cancer patients in China. We reviewed demographic and clinical data, and survival information of 420 young patients (20–45 years old) diagnosed with lung cancer in two Chinese hospitals between 2000 and 2013. The results showed that lung cancer occurred more frequently (70%) and affected more males than females (43.8% vs 26.7%) in patients older than 36; whereas, more females were affected under age 35 (16.7% vs 12.8%). Most patients had adenocarcinoma (67.6%) and stage IV disease (72.4%) at presentation. The median survival of all young patients with lung cancer was 44 months (95% CI: 39–49), of which patients with stage I–IIIA disease had a longer survival than those with stage IIIB/IV disease (101 vs 22 months, p < 0.001). No significant difference in survival was found in patients having different histological subtypes or genders. Multivariate analysis revealed that high exposure risk occupations, smoking, family history of lung cancer were risk factors of young lung cancer patients. This study provides an overview of the clinical characteristics, patterns and prognostic factors of young patients with lung cancer in China. |
format | Online Article Text |
id | pubmed-5687685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56876852017-11-20 Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions Li, Jianjie Yang, Fan Li, Xiao Zhang, Min Fu, Ruozi Yin, Xiaodan Wang, Jun Oncotarget Clinical Research Paper Limited data is available regarding lung cancer in Chinese young adults. This study was aimed to determine the characteristics, survival, and prognostic factors of young lung cancer patients in China. We reviewed demographic and clinical data, and survival information of 420 young patients (20–45 years old) diagnosed with lung cancer in two Chinese hospitals between 2000 and 2013. The results showed that lung cancer occurred more frequently (70%) and affected more males than females (43.8% vs 26.7%) in patients older than 36; whereas, more females were affected under age 35 (16.7% vs 12.8%). Most patients had adenocarcinoma (67.6%) and stage IV disease (72.4%) at presentation. The median survival of all young patients with lung cancer was 44 months (95% CI: 39–49), of which patients with stage I–IIIA disease had a longer survival than those with stage IIIB/IV disease (101 vs 22 months, p < 0.001). No significant difference in survival was found in patients having different histological subtypes or genders. Multivariate analysis revealed that high exposure risk occupations, smoking, family history of lung cancer were risk factors of young lung cancer patients. This study provides an overview of the clinical characteristics, patterns and prognostic factors of young patients with lung cancer in China. Impact Journals LLC 2017-07-12 /pmc/articles/PMC5687685/ /pubmed/29179515 http://dx.doi.org/10.18632/oncotarget.19183 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Li, Jianjie Yang, Fan Li, Xiao Zhang, Min Fu, Ruozi Yin, Xiaodan Wang, Jun Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions |
title | Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions |
title_full | Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions |
title_fullStr | Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions |
title_full_unstemmed | Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions |
title_short | Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions |
title_sort | characteristics, survival, and risk factors of chinese young lung cancer patients: the experience from two institutions |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687685/ https://www.ncbi.nlm.nih.gov/pubmed/29179515 http://dx.doi.org/10.18632/oncotarget.19183 |
work_keys_str_mv | AT lijianjie characteristicssurvivalandriskfactorsofchineseyounglungcancerpatientstheexperiencefromtwoinstitutions AT yangfan characteristicssurvivalandriskfactorsofchineseyounglungcancerpatientstheexperiencefromtwoinstitutions AT lixiao characteristicssurvivalandriskfactorsofchineseyounglungcancerpatientstheexperiencefromtwoinstitutions AT zhangmin characteristicssurvivalandriskfactorsofchineseyounglungcancerpatientstheexperiencefromtwoinstitutions AT furuozi characteristicssurvivalandriskfactorsofchineseyounglungcancerpatientstheexperiencefromtwoinstitutions AT yinxiaodan characteristicssurvivalandriskfactorsofchineseyounglungcancerpatientstheexperiencefromtwoinstitutions AT wangjun characteristicssurvivalandriskfactorsofchineseyounglungcancerpatientstheexperiencefromtwoinstitutions |