TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons

BACKGROUND: Local anaesthetics (LA) reduce neuronal excitability by inhibiting voltage-gated Na(+) channels. When applied at high concentrations in the direct vicinity of nerves, LAs can also induce relevant irritation and neurotoxicity via mechanisms involving an increase of intracellular Ca(2+). I...

Descripción completa

Detalles Bibliográficos
Autores principales: Eberhardt, Mirjam, Stueber, Thomas, de la Roche, Jeanne, Herzog, Christine, Leffler, Andreas, Reeh, Peter W., Kistner, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687772/
https://www.ncbi.nlm.nih.gov/pubmed/29141003
http://dx.doi.org/10.1371/journal.pone.0188008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687772/
https://www.ncbi.nlm.nih.gov/pubmed/29141003
http://dx.doi.org/10.1371/journal.pone.0188008

Ejemplares similares