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TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons

BACKGROUND: Local anaesthetics (LA) reduce neuronal excitability by inhibiting voltage-gated Na(+) channels. When applied at high concentrations in the direct vicinity of nerves, LAs can also induce relevant irritation and neurotoxicity via mechanisms involving an increase of intracellular Ca(2+). I...

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Detalles Bibliográficos
Autores principales:	Eberhardt, Mirjam, Stueber, Thomas, de la Roche, Jeanne, Herzog, Christine, Leffler, Andreas, Reeh, Peter W., Kistner, Katrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687772/ https://www.ncbi.nlm.nih.gov/pubmed/29141003 http://dx.doi.org/10.1371/journal.pone.0188008

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