A null mutation in SERPINE1 protects against biological aging in humans

Plasminogen activator inhibitor–1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models of accelerated aging, genetic deficiency and targeted inhibition of PAI-1 protect against aging-like pathology and prolong...

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Detalles Bibliográficos
Autores principales: Khan, Sadiya S., Shah, Sanjiv J., Klyachko, Ekaterina, Baldridge, Abigail S., Eren, Mesut, Place, Aaron T., Aviv, Abraham, Puterman, Eli, Lloyd-Jones, Donald M., Heiman, Meadow, Miyata, Toshio, Gupta, Sweta, Shapiro, Amy D., Vaughan, Douglas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687852/
https://www.ncbi.nlm.nih.gov/pubmed/29152572
http://dx.doi.org/10.1126/sciadv.aao1617

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