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Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications

In this study, the biocompatibility and in vitro degradation behaviour of a commercial zinc-based alloy (Zn-5 Al-4 Mg) were evaluated and compared with that of pure zinc for temporary orthopaedic implant applications. Biocompatibility tests were conducted using human alveolar lung epithelial cells (...

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Autores principales: Kannan, M. Bobby, Moore, Corey, Saptarshi, Shruti, Somasundaram, Sahadev, Rahuma, Mohamed, Lopata, Andreas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688075/
https://www.ncbi.nlm.nih.gov/pubmed/29142320
http://dx.doi.org/10.1038/s41598-017-15873-w
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author Kannan, M. Bobby
Moore, Corey
Saptarshi, Shruti
Somasundaram, Sahadev
Rahuma, Mohamed
Lopata, Andreas L.
author_facet Kannan, M. Bobby
Moore, Corey
Saptarshi, Shruti
Somasundaram, Sahadev
Rahuma, Mohamed
Lopata, Andreas L.
author_sort Kannan, M. Bobby
collection PubMed
description In this study, the biocompatibility and in vitro degradation behaviour of a commercial zinc-based alloy (Zn-5 Al-4 Mg) were evaluated and compared with that of pure zinc for temporary orthopaedic implant applications. Biocompatibility tests were conducted using human alveolar lung epithelial cells (A549), which showed that the zinc alloy exhibits similar biocompatibility as compared to pure zinc. In vitro degradation evaluation was performed using weight loss and electrochemical methods in simulated body fluid (SBF) at 37 °C. Weight loss measurements revealed that the degradation of the zinc alloy was slightly lower during the initial immersion period (1–3 days), but marginally increased after 5 and 7 days immersion as compared to pure zinc. Potentiodynamic polarisation experiments showed that the zinc alloy exhibits higher degradation rate than pure zinc. However, electrochemical impedance spectroscopy analysis suggests that pure zinc is susceptible to localized degradation, whereas the zinc alloy exhibited passivation behaviour. Post-degradation analysis revealed localized degradation in both pure zinc and the zinc alloy.
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spelling pubmed-56880752017-11-21 Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications Kannan, M. Bobby Moore, Corey Saptarshi, Shruti Somasundaram, Sahadev Rahuma, Mohamed Lopata, Andreas L. Sci Rep Article In this study, the biocompatibility and in vitro degradation behaviour of a commercial zinc-based alloy (Zn-5 Al-4 Mg) were evaluated and compared with that of pure zinc for temporary orthopaedic implant applications. Biocompatibility tests were conducted using human alveolar lung epithelial cells (A549), which showed that the zinc alloy exhibits similar biocompatibility as compared to pure zinc. In vitro degradation evaluation was performed using weight loss and electrochemical methods in simulated body fluid (SBF) at 37 °C. Weight loss measurements revealed that the degradation of the zinc alloy was slightly lower during the initial immersion period (1–3 days), but marginally increased after 5 and 7 days immersion as compared to pure zinc. Potentiodynamic polarisation experiments showed that the zinc alloy exhibits higher degradation rate than pure zinc. However, electrochemical impedance spectroscopy analysis suggests that pure zinc is susceptible to localized degradation, whereas the zinc alloy exhibited passivation behaviour. Post-degradation analysis revealed localized degradation in both pure zinc and the zinc alloy. Nature Publishing Group UK 2017-11-15 /pmc/articles/PMC5688075/ /pubmed/29142320 http://dx.doi.org/10.1038/s41598-017-15873-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kannan, M. Bobby
Moore, Corey
Saptarshi, Shruti
Somasundaram, Sahadev
Rahuma, Mohamed
Lopata, Andreas L.
Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
title Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
title_full Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
title_fullStr Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
title_full_unstemmed Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
title_short Biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
title_sort biocompatibility and biodegradation studies of a commercial zinc alloy for temporary mini-implant applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688075/
https://www.ncbi.nlm.nih.gov/pubmed/29142320
http://dx.doi.org/10.1038/s41598-017-15873-w
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