Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells

AL amyloidosis is characterized by widespread deposition of immunoglobulin light chains (LCs) as amyloid fibrils. Cardiac involvement is frequent and leads to life-threatening cardiomyopathy. Besides the tissue alteration caused by fibrils, clinical and experimental evidence indicates that cardiac d...

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Detalles Bibliográficos
Autores principales: Imperlini, Esther, Gnecchi, Massimiliano, Rognoni, Paola, Sabidò, Eduard, Ciuffreda, Maria Chiara, Palladini, Giovanni, Espadas, Guadalupe, Mancuso, Francesco Mattia, Bozzola, Margherita, Malpasso, Giuseppe, Valentini, Veronica, Palladini, Giuseppina, Orrù, Stefania, Ferraro, Giovanni, Milani, Paolo, Perlini, Stefano, Salvatore, Francesco, Merlini, Giampaolo, Lavatelli, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688098/
https://www.ncbi.nlm.nih.gov/pubmed/29142197
http://dx.doi.org/10.1038/s41598-017-15424-3

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