Polymer mimics of biomacromolecular antifreezes

Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as i...

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Autores principales: Biggs, Caroline I., Bailey, Trisha L., Ben Graham, Stubbs, Christopher, Fayter, Alice, Gibson, Matthew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688100/
https://www.ncbi.nlm.nih.gov/pubmed/29142216
http://dx.doi.org/10.1038/s41467-017-01421-7
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author Biggs, Caroline I.
Bailey, Trisha L.
Ben Graham
Stubbs, Christopher
Fayter, Alice
Gibson, Matthew I.
author_facet Biggs, Caroline I.
Bailey, Trisha L.
Ben Graham
Stubbs, Christopher
Fayter, Alice
Gibson, Matthew I.
author_sort Biggs, Caroline I.
collection PubMed
description Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced.
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spelling pubmed-56881002017-11-17 Polymer mimics of biomacromolecular antifreezes Biggs, Caroline I. Bailey, Trisha L. Ben Graham Stubbs, Christopher Fayter, Alice Gibson, Matthew I. Nat Commun Review Article Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced. Nature Publishing Group UK 2017-11-16 /pmc/articles/PMC5688100/ /pubmed/29142216 http://dx.doi.org/10.1038/s41467-017-01421-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Biggs, Caroline I.
Bailey, Trisha L.
Ben Graham
Stubbs, Christopher
Fayter, Alice
Gibson, Matthew I.
Polymer mimics of biomacromolecular antifreezes
title Polymer mimics of biomacromolecular antifreezes
title_full Polymer mimics of biomacromolecular antifreezes
title_fullStr Polymer mimics of biomacromolecular antifreezes
title_full_unstemmed Polymer mimics of biomacromolecular antifreezes
title_short Polymer mimics of biomacromolecular antifreezes
title_sort polymer mimics of biomacromolecular antifreezes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688100/
https://www.ncbi.nlm.nih.gov/pubmed/29142216
http://dx.doi.org/10.1038/s41467-017-01421-7
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