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Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats

Hypertrophic pancreatic islets (PI) of Goto Kakizaki (GK) diabetic rats contain a lower number of β-cells vs. non-diabetic Wistar rat PI. Remaining β-cells contain reduced mitochondrial (mt) DNA per nucleus (copy number), probably due to declining mtDNA replication machinery, decreased mt biogenesis...

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Detalles Bibliográficos
Autores principales:	Špaček, Tomáš, Pavluch, Vojtěch, Alán, Lukáš, Capková, Nikola, Engstová, Hana, Dlasková, Andrea, Berková, Zuzana, Saudek, František, Ježek, Petr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688109/ https://www.ncbi.nlm.nih.gov/pubmed/29142323 http://dx.doi.org/10.1038/s41598-017-15958-6

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