Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Many compounds with potentially reactive chemical motifs and poor physicochemical properties are published as selective modulators of biomolecules without sufficient validation and then propagated in the scientific literature as useful chemical probes. Several histone acetyltransferase (HAT) inhibit...

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Detalles Bibliográficos
Autores principales: Dahlin, Jayme L., Nelson, Kathryn M., Strasser, Jessica M., Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena M., Organ, Shawna, Cuellar, Matthew, Singh, Gurpreet, Shrimp, Jonathan H., Nguyen, Nghi, Meier, Jordan L., Arrowsmith, Cheryl H., Brown, Peter J., Baell, Jonathan B., Walters, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688144/
https://www.ncbi.nlm.nih.gov/pubmed/29142305
http://dx.doi.org/10.1038/s41467-017-01657-3

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