Cargando…
Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring
This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Ts...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688151/ https://www.ncbi.nlm.nih.gov/pubmed/29142304 http://dx.doi.org/10.1038/s41598-017-15529-9 |
_version_ | 1783279097230655488 |
---|---|
author | Serrano-Nascimento, Caroline Salgueiro, Rafael Barrera Pantaleão, Thiago Corrêa da Costa, Vânia Maria Nunes, Maria Tereza |
author_facet | Serrano-Nascimento, Caroline Salgueiro, Rafael Barrera Pantaleão, Thiago Corrêa da Costa, Vânia Maria Nunes, Maria Tereza |
author_sort | Serrano-Nascimento, Caroline |
collection | PubMed |
description | This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Tsh expression and secretion in the adult male offspring. Moreover, the IE-exposed offspring rats presented reduced thyroid hormones levels, morphological alterations in the thyroid follicles, increased thyroid oxidative stress and decreased expression of thyroid differentiation markers (Tshr, Nis, Tg, Tpo, Mct8) and thyroid transcription factors (Nkx2.1, Pax8). Finally, the data presented here strongly suggest that epigenetic mechanisms, as increased DNA methylation, augmented DNA methyltransferases expression, hypermethylation of histone H3, hypoaceylation of histones H3 and H4, increased expression/activity of histone deacetylases and decreased expression/activity of histone acetyltransferases are involved in the repression of thyroid gene expression in the adult male offspring. In conclusion, our results indicate that rat dams’ exposure to IE during pregnancy and lactation induces primary hypothyroidism and triggers several epigenetic changes in the thyroid gland of their male offspring in adulthood. |
format | Online Article Text |
id | pubmed-5688151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56881512017-11-24 Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring Serrano-Nascimento, Caroline Salgueiro, Rafael Barrera Pantaleão, Thiago Corrêa da Costa, Vânia Maria Nunes, Maria Tereza Sci Rep Article This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Tsh expression and secretion in the adult male offspring. Moreover, the IE-exposed offspring rats presented reduced thyroid hormones levels, morphological alterations in the thyroid follicles, increased thyroid oxidative stress and decreased expression of thyroid differentiation markers (Tshr, Nis, Tg, Tpo, Mct8) and thyroid transcription factors (Nkx2.1, Pax8). Finally, the data presented here strongly suggest that epigenetic mechanisms, as increased DNA methylation, augmented DNA methyltransferases expression, hypermethylation of histone H3, hypoaceylation of histones H3 and H4, increased expression/activity of histone deacetylases and decreased expression/activity of histone acetyltransferases are involved in the repression of thyroid gene expression in the adult male offspring. In conclusion, our results indicate that rat dams’ exposure to IE during pregnancy and lactation induces primary hypothyroidism and triggers several epigenetic changes in the thyroid gland of their male offspring in adulthood. Nature Publishing Group UK 2017-11-15 /pmc/articles/PMC5688151/ /pubmed/29142304 http://dx.doi.org/10.1038/s41598-017-15529-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Serrano-Nascimento, Caroline Salgueiro, Rafael Barrera Pantaleão, Thiago Corrêa da Costa, Vânia Maria Nunes, Maria Tereza Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring |
title | Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring |
title_full | Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring |
title_fullStr | Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring |
title_full_unstemmed | Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring |
title_short | Maternal Exposure to Iodine Excess Throughout Pregnancy and Lactation Induces Hypothyroidism in Adult Male Rat Offspring |
title_sort | maternal exposure to iodine excess throughout pregnancy and lactation induces hypothyroidism in adult male rat offspring |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688151/ https://www.ncbi.nlm.nih.gov/pubmed/29142304 http://dx.doi.org/10.1038/s41598-017-15529-9 |
work_keys_str_mv | AT serranonascimentocaroline maternalexposuretoiodineexcessthroughoutpregnancyandlactationinduceshypothyroidisminadultmaleratoffspring AT salgueirorafaelbarrera maternalexposuretoiodineexcessthroughoutpregnancyandlactationinduceshypothyroidisminadultmaleratoffspring AT pantaleaothiago maternalexposuretoiodineexcessthroughoutpregnancyandlactationinduceshypothyroidisminadultmaleratoffspring AT correadacostavaniamaria maternalexposuretoiodineexcessthroughoutpregnancyandlactationinduceshypothyroidisminadultmaleratoffspring AT nunesmariatereza maternalexposuretoiodineexcessthroughoutpregnancyandlactationinduceshypothyroidisminadultmaleratoffspring |