The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was originally described as an antibacterial compound. Here we show that carolacton targets FolD, a key enzyme from the folate-dependent C1 metabolism. We characterize the inter...

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Detalles Bibliográficos
Autores principales: Fu, Chengzhang, Sikandar, Asfandyar, Donner, Jannik, Zaburannyi, Nestor, Herrmann, Jennifer, Reck, Michael, Wagner-Döbler, Irene, Koehnke, Jesko, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688156/
https://www.ncbi.nlm.nih.gov/pubmed/29142318
http://dx.doi.org/10.1038/s41467-017-01671-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688156/
https://www.ncbi.nlm.nih.gov/pubmed/29142318
http://dx.doi.org/10.1038/s41467-017-01671-5

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