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The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was originally described as an antibacterial compound. Here we show that carolacton targets FolD, a key enzyme from the folate-dependent C1 metabolism. We characterize the inter...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688156/ https://www.ncbi.nlm.nih.gov/pubmed/29142318 http://dx.doi.org/10.1038/s41467-017-01671-5 |