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The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity
The aim of the present study was to evaluate the funtion of fenugreek seed mucilage (FSM) as potential matrix forming agent for orodispersible pharmaceutical lyophilisates. The FSM was isolated and characterized. FSM colloidal dispersions were prepared and the rheological evaluation was performed. O...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688226/ https://www.ncbi.nlm.nih.gov/pubmed/29204071 http://dx.doi.org/10.1016/j.jsps.2017.09.006 |
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author | Iurian, Sonia Dinte, Elena Iuga, Cristina Bogdan, Cătălina Spiridon, Iuliana Barbu-Tudoran, Lucian Bodoki, Andreea Tomuţă, Ioan Leucuţa, Sorin E. |
author_facet | Iurian, Sonia Dinte, Elena Iuga, Cristina Bogdan, Cătălina Spiridon, Iuliana Barbu-Tudoran, Lucian Bodoki, Andreea Tomuţă, Ioan Leucuţa, Sorin E. |
author_sort | Iurian, Sonia |
collection | PubMed |
description | The aim of the present study was to evaluate the funtion of fenugreek seed mucilage (FSM) as potential matrix forming agent for orodispersible pharmaceutical lyophilisates. The FSM was isolated and characterized. FSM colloidal dispersions were prepared and the rheological evaluation was performed. Oral lyophilisates (OLs) with different FSM concentrations, containing meloxicam as model drug were prepared by freeze drying method. The OLs were characterized and compared to gelatin containing tablets, prepared under the same conditions. The FSM dispersions revealed shear thinning flow type. Based on colloidal dispersions' rheological properties, five FSM concentrations were taken forward to the lyophilization step. Completely dry and elegant tablets were obtained. Texture analysis indicated highly porous structures, confirmed by SEM analysis, which explain the fast disintegration properties. All the prepared tablets disintegrated in less than 47 s. The disintegration process was prolonged by the increase in FSM content, due to the high viscosity the polymer creates in aqueous media. FSM tablets presented longer disintegration times, as compared to gelatin tablets, but also higher crushing strength. Considering the fast disintegration and the high crushing strength, FSM is a good candidate as matrix forming agent for fast disintegrating dosage forms or other freeze-dried preparations. |
format | Online Article Text |
id | pubmed-5688226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56882262017-12-04 The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity Iurian, Sonia Dinte, Elena Iuga, Cristina Bogdan, Cătălina Spiridon, Iuliana Barbu-Tudoran, Lucian Bodoki, Andreea Tomuţă, Ioan Leucuţa, Sorin E. Saudi Pharm J Original Article The aim of the present study was to evaluate the funtion of fenugreek seed mucilage (FSM) as potential matrix forming agent for orodispersible pharmaceutical lyophilisates. The FSM was isolated and characterized. FSM colloidal dispersions were prepared and the rheological evaluation was performed. Oral lyophilisates (OLs) with different FSM concentrations, containing meloxicam as model drug were prepared by freeze drying method. The OLs were characterized and compared to gelatin containing tablets, prepared under the same conditions. The FSM dispersions revealed shear thinning flow type. Based on colloidal dispersions' rheological properties, five FSM concentrations were taken forward to the lyophilization step. Completely dry and elegant tablets were obtained. Texture analysis indicated highly porous structures, confirmed by SEM analysis, which explain the fast disintegration properties. All the prepared tablets disintegrated in less than 47 s. The disintegration process was prolonged by the increase in FSM content, due to the high viscosity the polymer creates in aqueous media. FSM tablets presented longer disintegration times, as compared to gelatin tablets, but also higher crushing strength. Considering the fast disintegration and the high crushing strength, FSM is a good candidate as matrix forming agent for fast disintegrating dosage forms or other freeze-dried preparations. Elsevier 2017-12 2017-09-17 /pmc/articles/PMC5688226/ /pubmed/29204071 http://dx.doi.org/10.1016/j.jsps.2017.09.006 Text en © 2017 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Iurian, Sonia Dinte, Elena Iuga, Cristina Bogdan, Cătălina Spiridon, Iuliana Barbu-Tudoran, Lucian Bodoki, Andreea Tomuţă, Ioan Leucuţa, Sorin E. The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity |
title | The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity |
title_full | The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity |
title_fullStr | The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity |
title_full_unstemmed | The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity |
title_short | The pharmaceutical applications of a biopolymer isolated from Trigonella foenum-graecum seeds: Focus on the freeze-dried matrix forming capacity |
title_sort | pharmaceutical applications of a biopolymer isolated from trigonella foenum-graecum seeds: focus on the freeze-dried matrix forming capacity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688226/ https://www.ncbi.nlm.nih.gov/pubmed/29204071 http://dx.doi.org/10.1016/j.jsps.2017.09.006 |
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