Cargando…

Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients

OBJECTIVE: This study investigated whether pretreatment oxidative stress, measured by lipid hydroperoxides (LPH), 4-hydroxy-2-nonenal (4-HNE), 8-isoprostane (8-ISO), and malondialdehyde (MDA), was associated with improvement in immediate recall among n-3 PUFA-treated coronary artery disease patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazereeuw, Graham, Herrmann, Nathan, Andreazza, Ana C., Scola, Gustavo, Ma, David W. L., Oh, Paul I., Lanctôt, Krista L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688343/
https://www.ncbi.nlm.nih.gov/pubmed/29230323
http://dx.doi.org/10.1155/2017/3674371
_version_ 1783279141480562688
author Mazereeuw, Graham
Herrmann, Nathan
Andreazza, Ana C.
Scola, Gustavo
Ma, David W. L.
Oh, Paul I.
Lanctôt, Krista L.
author_facet Mazereeuw, Graham
Herrmann, Nathan
Andreazza, Ana C.
Scola, Gustavo
Ma, David W. L.
Oh, Paul I.
Lanctôt, Krista L.
author_sort Mazereeuw, Graham
collection PubMed
description OBJECTIVE: This study investigated whether pretreatment oxidative stress, measured by lipid hydroperoxides (LPH), 4-hydroxy-2-nonenal (4-HNE), 8-isoprostane (8-ISO), and malondialdehyde (MDA), was associated with improvement in immediate recall among n-3 PUFA-treated coronary artery disease patients. METHODS: This was a secondary analysis of the CAROTID trial (NCT00981383). Composite immediate recall, measured using the California Verbal Learning Test, Second Edition, and the Brief Visuospatial Memory Test-Revised, was assessed. LPH, 4-HNE, 8-ISO, MDA, and n-3 PUFA concentrations were analysed from fasting blood. Patients then received either n-3 PUFA treatment or placebo for 12 weeks, after which composite immediate recall was reassessed. Linear regression was used to investigate relationships between lipid peroxidation markers and changes in composite immediate recall in each treatment group. RESULTS: Eighty-five patients (age = 61.1 ± 8.5, 77% male, mean years of education = 15.3 ± 3.4) were included (n = 46 placebo, n = 39 n-3 PUFA). After adjusting for multiple comparisons and potential confounders, greater baseline concentrations of LPH (β = 0.45, p = .002) and 4-HNE (β = 0.38, p = .005) were associated with greater improvement in composite immediate recall among n-3 PUFA-treated patients. No other associations were observed. CONCLUSIONS: N-3 PUFA treatment may be more likely to improve immediate recall in patients with greater oxidative stress.
format Online
Article
Text
id pubmed-5688343
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-56883432017-12-11 Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients Mazereeuw, Graham Herrmann, Nathan Andreazza, Ana C. Scola, Gustavo Ma, David W. L. Oh, Paul I. Lanctôt, Krista L. Cardiovasc Psychiatry Neurol Research Article OBJECTIVE: This study investigated whether pretreatment oxidative stress, measured by lipid hydroperoxides (LPH), 4-hydroxy-2-nonenal (4-HNE), 8-isoprostane (8-ISO), and malondialdehyde (MDA), was associated with improvement in immediate recall among n-3 PUFA-treated coronary artery disease patients. METHODS: This was a secondary analysis of the CAROTID trial (NCT00981383). Composite immediate recall, measured using the California Verbal Learning Test, Second Edition, and the Brief Visuospatial Memory Test-Revised, was assessed. LPH, 4-HNE, 8-ISO, MDA, and n-3 PUFA concentrations were analysed from fasting blood. Patients then received either n-3 PUFA treatment or placebo for 12 weeks, after which composite immediate recall was reassessed. Linear regression was used to investigate relationships between lipid peroxidation markers and changes in composite immediate recall in each treatment group. RESULTS: Eighty-five patients (age = 61.1 ± 8.5, 77% male, mean years of education = 15.3 ± 3.4) were included (n = 46 placebo, n = 39 n-3 PUFA). After adjusting for multiple comparisons and potential confounders, greater baseline concentrations of LPH (β = 0.45, p = .002) and 4-HNE (β = 0.38, p = .005) were associated with greater improvement in composite immediate recall among n-3 PUFA-treated patients. No other associations were observed. CONCLUSIONS: N-3 PUFA treatment may be more likely to improve immediate recall in patients with greater oxidative stress. Hindawi 2017 2017-11-02 /pmc/articles/PMC5688343/ /pubmed/29230323 http://dx.doi.org/10.1155/2017/3674371 Text en Copyright © 2017 Graham Mazereeuw et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mazereeuw, Graham
Herrmann, Nathan
Andreazza, Ana C.
Scola, Gustavo
Ma, David W. L.
Oh, Paul I.
Lanctôt, Krista L.
Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients
title Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients
title_full Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients
title_fullStr Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients
title_full_unstemmed Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients
title_short Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients
title_sort baseline oxidative stress is associated with memory changes in omega-3 fatty acid treated coronary artery disease patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688343/
https://www.ncbi.nlm.nih.gov/pubmed/29230323
http://dx.doi.org/10.1155/2017/3674371
work_keys_str_mv AT mazereeuwgraham baselineoxidativestressisassociatedwithmemorychangesinomega3fattyacidtreatedcoronaryarterydiseasepatients
AT herrmannnathan baselineoxidativestressisassociatedwithmemorychangesinomega3fattyacidtreatedcoronaryarterydiseasepatients
AT andreazzaanac baselineoxidativestressisassociatedwithmemorychangesinomega3fattyacidtreatedcoronaryarterydiseasepatients
AT scolagustavo baselineoxidativestressisassociatedwithmemorychangesinomega3fattyacidtreatedcoronaryarterydiseasepatients
AT madavidwl baselineoxidativestressisassociatedwithmemorychangesinomega3fattyacidtreatedcoronaryarterydiseasepatients
AT ohpauli baselineoxidativestressisassociatedwithmemorychangesinomega3fattyacidtreatedcoronaryarterydiseasepatients
AT lanctotkristal baselineoxidativestressisassociatedwithmemorychangesinomega3fattyacidtreatedcoronaryarterydiseasepatients