The enduring legacy of the “constant-field equation” in membrane ion transport

In 1943, David Goldman published a seminal paper in The Journal of General Physiology that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theoretical pillar used to interpret the relationship between a...

Descripción completa

Detalles Bibliográficos
Autores principales: Alvarez, Osvaldo, Latorre, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688357/
https://www.ncbi.nlm.nih.gov/pubmed/28931632
http://dx.doi.org/10.1085/jgp.201711839
_version_ 1783279144693399552
author Alvarez, Osvaldo
Latorre, Ramon
author_facet Alvarez, Osvaldo
Latorre, Ramon
author_sort Alvarez, Osvaldo
collection PubMed
description In 1943, David Goldman published a seminal paper in The Journal of General Physiology that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theoretical pillar used to interpret the relationship between a cell’s membrane potential and its external and/or internal ionic composition. Here, we describe from an historical perspective the theory underlying the constant-field equation and its application to membrane ion transport.
format Online
Article
Text
id pubmed-5688357
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-56883572018-04-02 The enduring legacy of the “constant-field equation” in membrane ion transport Alvarez, Osvaldo Latorre, Ramon J Gen Physiol Reviews In 1943, David Goldman published a seminal paper in The Journal of General Physiology that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theoretical pillar used to interpret the relationship between a cell’s membrane potential and its external and/or internal ionic composition. Here, we describe from an historical perspective the theory underlying the constant-field equation and its application to membrane ion transport. The Rockefeller University Press 2017-10-02 /pmc/articles/PMC5688357/ /pubmed/28931632 http://dx.doi.org/10.1085/jgp.201711839 Text en © 2017 Alvarez and Latorre http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Alvarez, Osvaldo
Latorre, Ramon
The enduring legacy of the “constant-field equation” in membrane ion transport
title The enduring legacy of the “constant-field equation” in membrane ion transport
title_full The enduring legacy of the “constant-field equation” in membrane ion transport
title_fullStr The enduring legacy of the “constant-field equation” in membrane ion transport
title_full_unstemmed The enduring legacy of the “constant-field equation” in membrane ion transport
title_short The enduring legacy of the “constant-field equation” in membrane ion transport
title_sort enduring legacy of the “constant-field equation” in membrane ion transport
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688357/
https://www.ncbi.nlm.nih.gov/pubmed/28931632
http://dx.doi.org/10.1085/jgp.201711839
work_keys_str_mv AT alvarezosvaldo theenduringlegacyoftheconstantfieldequationinmembraneiontransport
AT latorreramon theenduringlegacyoftheconstantfieldequationinmembraneiontransport
AT alvarezosvaldo enduringlegacyoftheconstantfieldequationinmembraneiontransport
AT latorreramon enduringlegacyoftheconstantfieldequationinmembraneiontransport

Ejemplares similares