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Proteobacteria: A Common Factor in Human Diseases

Microbiota represents the entire microbial community present in the gut host. It serves several functions establishing a mutualistic relation with the host. Latest years have seen a burst in the number of studies focusing on this topic, in particular on intestinal diseases. In this scenario, Proteob...

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Detalles Bibliográficos
Autores principales: Rizzatti, G., Lopetuso, L. R., Gibiino, G., Binda, C., Gasbarrini, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688358/
https://www.ncbi.nlm.nih.gov/pubmed/29230419
http://dx.doi.org/10.1155/2017/9351507
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author Rizzatti, G.
Lopetuso, L. R.
Gibiino, G.
Binda, C.
Gasbarrini, A.
author_facet Rizzatti, G.
Lopetuso, L. R.
Gibiino, G.
Binda, C.
Gasbarrini, A.
author_sort Rizzatti, G.
collection PubMed
description Microbiota represents the entire microbial community present in the gut host. It serves several functions establishing a mutualistic relation with the host. Latest years have seen a burst in the number of studies focusing on this topic, in particular on intestinal diseases. In this scenario, Proteobacteria are one of the most abundant phyla, comprising several known human pathogens. This review highlights the latest findings on the role of Proteobacteria not only in intestinal but also in extraintestinal diseases. Indeed, an increasing amount of data identifies Proteobacteria as a possible microbial signature of disease. Several studies demonstrate an increased abundance of members belonging to this phylum in such conditions. Major evidences currently involve metabolic disorders and inflammatory bowel disease. However, more recent studies suggest a role also in lung diseases, such as asthma and chronic obstructive pulmonary disease, but evidences are still scant. Notably, all these conditions are sustained by various degree of inflammation, which thus represents a core aspect of Proteobacteria-related diseases.
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spelling pubmed-56883582017-12-11 Proteobacteria: A Common Factor in Human Diseases Rizzatti, G. Lopetuso, L. R. Gibiino, G. Binda, C. Gasbarrini, A. Biomed Res Int Review Article Microbiota represents the entire microbial community present in the gut host. It serves several functions establishing a mutualistic relation with the host. Latest years have seen a burst in the number of studies focusing on this topic, in particular on intestinal diseases. In this scenario, Proteobacteria are one of the most abundant phyla, comprising several known human pathogens. This review highlights the latest findings on the role of Proteobacteria not only in intestinal but also in extraintestinal diseases. Indeed, an increasing amount of data identifies Proteobacteria as a possible microbial signature of disease. Several studies demonstrate an increased abundance of members belonging to this phylum in such conditions. Major evidences currently involve metabolic disorders and inflammatory bowel disease. However, more recent studies suggest a role also in lung diseases, such as asthma and chronic obstructive pulmonary disease, but evidences are still scant. Notably, all these conditions are sustained by various degree of inflammation, which thus represents a core aspect of Proteobacteria-related diseases. Hindawi 2017 2017-11-02 /pmc/articles/PMC5688358/ /pubmed/29230419 http://dx.doi.org/10.1155/2017/9351507 Text en Copyright © 2017 G. Rizzatti et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rizzatti, G.
Lopetuso, L. R.
Gibiino, G.
Binda, C.
Gasbarrini, A.
Proteobacteria: A Common Factor in Human Diseases
title Proteobacteria: A Common Factor in Human Diseases
title_full Proteobacteria: A Common Factor in Human Diseases
title_fullStr Proteobacteria: A Common Factor in Human Diseases
title_full_unstemmed Proteobacteria: A Common Factor in Human Diseases
title_short Proteobacteria: A Common Factor in Human Diseases
title_sort proteobacteria: a common factor in human diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688358/
https://www.ncbi.nlm.nih.gov/pubmed/29230419
http://dx.doi.org/10.1155/2017/9351507
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